Document Detail

Total body protein mass: validation of total body potassium prediction model in children and adolescents.
MedLine Citation:
PMID:  16549470     Owner:  NLM     Status:  MEDLINE    
Protein is an important body component for monitoring growth, development, and nutritional status. We previously developed a total body potassium (TBK, in mmol) and bone mineral (Mo, in kg) model for predicting total body protein (TBPro, in kg) in adults (TBPro = 0.00252 x TBK + 0.732 x Mo). However, the applicability of the TBK-Mo model for children is unknown. The study aims were to develop a TBK-independent 6-component (6-C) TBPro approach as the criterion, and then to validate the TBK-Mo model in children. The following measurements were made in adolescents and children (n = 62, 38 boys and 24 girls, aged 5-17 y): body weight (BW, in kg), body volume (BV, in liters) by air displacement plethysmography, total body water (TBW, in kg) by 2H2O dilution, Mo by dual-energy X-ray absorptiometry, and TBK by whole-body counting. A 6-C model was derived as TBPro = 2.922 x BW - 0.301 x TBW - 2.039 x Mo - 2.632 x BV. The TBPro estimates did not differ between the 6-C and TBK-Mo models (mean +/- SD, 0.20 +/- 0.86 kg). There was a significant correlation between TBPro by the 6-C and TBK-Mo models (r = 0.94, P < 0.001). Bland-Altman analysis indicated that the differences between TBPro by 6-C and TBK-Mo models were not significantly correlated with the mean TBPro estimates by the 2 models (r = 0.032, P > 0.05). The TBK-Mo model can thus be used to estimate TBPro in healthy adults, adolescents, and children > 5 y old.
ZiMian Wang; Stanley Heshka; Jack Wang; Steven B Heymsfield
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The Journal of nutrition     Volume:  136     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-03-21     Completed Date:  2006-05-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1032-6     Citation Subset:  IM    
Obesity Research Center, St. Luke's-Roosevelt Hospital, Columbia University College of Physicians and Surgeons, New York, NY, USA.
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MeSH Terms
Absorptiometry, Photon
Adipose Tissue
Body Composition*
Body Mass Index
Body Water
Body Weight
Bone Density
Child, Preschool
Deuterium / diagnostic use
Models, Biological
Potassium / analysis*
Proteins / analysis*
Grant Support
P01-42618//PHS HHS
Reg. No./Substance:
0/Proteins; 7440-09-7/Potassium; 7782-39-0/Deuterium

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