Document Detail

Total body catecholamine kinetics before and after birth in spontaneously hypoxemic fetal lambs.
MedLine Citation:
PMID:  10564202     Owner:  NLM     Status:  MEDLINE    
To study the effect of fetal hypoxemia on perinatal norepinephrine and epinephrine total body kinetics, 13 near-term fetal lambs were instrumented with vascular catheters under general anesthesia. One week later, norepinephrine and epinephrine kinetics were measured in normoxemic (n = 7) or spontaneously hypoxemic fetuses (n = 6) with isotope dilution methodology. Hypoxemic fetuses had lower body (P < 0.02) and placental (P = 0.01) weights and a threefold elevation in plasma norepinephrine (P < 0.005) and epinephrine (P < 0.025) associated with correspondingly higher total body norepinephrine (P < 0.005) and epinephrine (P < 0.05) spillovers. After birth, total body norepinephrine and epinephrine spillover increased 45% and 3.2-fold, respectively, in normoxemic animals (both P < 0.001). However, in the hypoxemic group, norepinephrine total body spillover was unchanged between fetal and 1-h lambs and then fell in 4-h lambs (P < 0.005). In addition, total body epinephrine release rose postnatally (P < 0.05) but less than in the normoxemic group (P < 0.02). No differences in norepinephrine or epinephrine total body clearance occurred between normoxemic and hypoxemic groups in either fetal or newborn lambs. These findings indicate that in hypoxemic and growth-restricted fetuses 1) elevated circulating norepinephrine and epinephrine levels are related to increased sympathoadrenal activity and 2) birth is associated with an initial maintenance and subsequent decline in global sympathetic activity but a blunting of adrenal medullary activation.
J J Smolich; M D Esler
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  277     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1999 Nov 
Date Detail:
Created Date:  1999-12-20     Completed Date:  1999-12-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R1313-20     Citation Subset:  IM    
Centre for Heart and Chest Research, Department of Medicine, Monash University, Clayton, Victoria 3168, Australia.
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MeSH Terms
Animals, Newborn / blood,  metabolism*,  physiology
Anoxia / metabolism*,  pathology,  physiopathology
Body Weight
Epinephrine / blood,  metabolism*
Fetal Blood
Fetal Diseases / metabolism*,  pathology,  physiopathology
Fetus / metabolism*,  physiology
Gases / blood
Norepinephrine / blood,  metabolism*
Sheep / embryology
Reg. No./Substance:
0/Gases; 51-41-2/Norepinephrine; 51-43-4/Epinephrine

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