Document Detail

Total blood eosinophils, serum eosinophil cationic protein and eosinophil protein X in childhood asthma: relation to disease status and therapy.
MedLine Citation:
PMID:  8221257     Owner:  NLM     Status:  MEDLINE    
Blood eosinophils, and serum levels of the eosinophil proteins, eosinophil cationic protein (ECP) and eosinophil protein X (EPX) were measured in childhood asthma. Seventeen patients mean age 11.9 years who were symptomatic with asthma, were enrolled in a study examining the eosinophil counts and eosinophil proteins at the onset of study and after treatment in relation to changes in their baseline forced expiratory volume at 1 second (FEV1) and % predicted FEV1. The patients with symptomatic asthma were compared with 17 patients mean age 12.0 years with asymptomatic asthma maintained on daily inhaled steroid and 13 patients, mean age 12.0 years, without asthma but with urticaria who served as non-asthma controls. Patients with symptomatic asthma did not have significantly higher initial eosinophil counts compared with those with asymptomatic asthma (0.43 x 10(9)/l vs 0.26 x 10(9)/l, P = 0.09) but had higher serum ECP levels (28.9 micrograms/l vs 18.5 micrograms/l). Both asthma patient groups had significantly higher serum ECP levels (P < 0.01) than the controls (9.8 micrograms/l). After therapy consisting of increased dose of inhaled steroids and/or oral steroids, patients in the symptomatic asthma group demonstrated a significant rise in FEV1 (1.67 l/sec at Visit 1 vs 2.08 l/sec at Visit 2, P < 0.001). A similar rise was seen for % predicted FEV1.(ABSTRACT TRUNCATED AT 250 WORDS)
B Zimmerman; A Lanner; I Enander; R S Zimmerman; C G Peterson; S Ahlstedt
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology     Volume:  23     ISSN:  0954-7894     ISO Abbreviation:  Clin. Exp. Allergy     Publication Date:  1993 Jul 
Date Detail:
Created Date:  1993-11-29     Completed Date:  1993-11-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8906443     Medline TA:  Clin Exp Allergy     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  564-70     Citation Subset:  IM    
Adverse Reaction Clinic Inc., Toronto, Canada.
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MeSH Terms
Administration, Inhalation
Administration, Oral
Asthma / blood*,  drug therapy
Blood Proteins / analysis*
Bronchodilator Agents / therapeutic use
Eosinophil Granule Proteins
Eosinophil-Derived Neurotoxin
Forced Expiratory Volume
Leukocyte Count
Prednisone / therapeutic use
Reg. No./Substance:
0/Blood Proteins; 0/Bronchodilator Agents; 0/Eosinophil Granule Proteins; 53-03-2/Prednisone; EC 3.1.-/Eosinophil-Derived Neurotoxin; EC 3.1.-/Ribonucleases

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