Document Detail


Total bacterial counts on oral mucosa after using a commercial saliva substitute in patients undergoing hematopoietic cell transplantation.
MedLine Citation:
PMID:  19960207     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: The commercial saliva substitute Oralbalance has been reported to alleviate symptoms of postradiotherapy xerostomia in head and neck cancer patients. Oralbalance may also be effective for xerostomia in patients undergoing hematopoietic cell transplantation (HCT) with high-dose chemotherapy and total-body irradiation. However, HCT patients are in a severely compromised condition, and saliva substitute must not promote infection. We reported previously that Oralbalance has antimicrobial effects against microbial species detected during HCT in vitro. This study was performed to determine the in vivo effects of Oralbalance on oral mucosal total bacterial counts in patients undergoing HCT. METHODS: A total of 18 neutropenic patients undergoing HCT were enrolled in this study. Before and after 1 week of Oralbalance use, bacterial samples were obtained from patients by wiping an area of varphi1 cm on the buccal mucosa with sterilized cotton swabs. Total bacterial counts of the obtained samples were examined by quantitative polymerase chain reaction amplification of the bacterial 16S ribosomal RNA gene. As controls, bacterial samples were also obtained from ten healthy subjects, and total bacterial counts were examined. RESULTS: No significant increase in bacterial count was observed with use of Oralbalance. None of the patients showed bacterial counts above the range found in healthy controls after using Oralbalance. CONCLUSIONS: In neutropenic patients undergoing HCT, Oralbalance did not increase the total counts of oral mucosal bacteria beyond the range found in healthy controls. Oral care using Oralbalance may alleviate the symptoms induced by hyposalivation without promoting infection.
Authors:
Yuko Sugiura; Yoshihiko Soga; Kokoro Yamabe; Soichiro Tsutani; Ichiro Tanimoto; Hiroshi Maeda; Susumu Kokeguchi; Nobuharu Fujii; Fumihiko Ishimaru; Mitsune Tanimoto; Fusanori Nishimura; Shogo Takashiba
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-12-05
Journal Detail:
Title:  Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer     Volume:  18     ISSN:  1433-7339     ISO Abbreviation:  Support Care Cancer     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-03     Completed Date:  2010-06-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9302957     Medline TA:  Support Care Cancer     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  395-8     Citation Subset:  IM    
Affiliation:
Department of Pathophysiology-Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama 700-8525, Japan.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adult
Colony Count, Microbial
Hematopoietic Stem Cell Transplantation / adverse effects*
Humans
Mouth Mucosa / microbiology*
Mouthwashes / pharmacology
Neutropenia / therapy*
Saliva, Artificial / pharmacology*
Xerostomia / drug therapy*,  etiology,  microbiology*
Chemical
Reg. No./Substance:
0/Mouthwashes; 0/Saliva, Artificial

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