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Total antioxidant status in the blood serum of rats after biogenic amines administration.
MedLine Citation:
PMID:  21491824     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
MATERIAL AND METHOD: We worked on three series of Wistar male rats. Series I received histamine (10 mg/kg body) intra peritoneal (i.p.) single dose, Series II received tyramine (10 mg/kg body) intra peritoneal (i.p.) single dose and Series III received biogenic amines mixture (histamine, tyramine and cadaverine 5 mg/kg body) intra peritoneal (i.p.) single dose. At 72 hours after biogenic amines administration blood samples were collected and total antioxidant status was determined using a RANDOX kit for manual use.
RESULTS: Our data shows that total antioxidant status present a significant decrease after 72 hours after amines administration as compared with initial moment, before administration.
CONCLUSIONS: The biogenic amines decrease the level of the total oxidant status in rat blood serum and reduce the capacity of the antioxidant defense system. The amines administration as a mixture seems to have no cumulative effect on individual amine toxicity.
Authors:
Nina Zamosteanu; Cristiana Filip; Elena Albu; Didona Ungureanu; Rodica Cuciureanu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i     Volume:  113     ISSN:  0048-7848     ISO Abbreviation:  Rev Med Chir Soc Med Nat Iasi     Publication Date:    2009 Apr-Jun
Date Detail:
Created Date:  2011-04-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0413735     Medline TA:  Rev Med Chir Soc Med Nat Iasi     Country:  Romania    
Other Details:
Languages:  eng     Pagination:  502-4     Citation Subset:  IM    
Affiliation:
School of Medicine, Department of Biochemistry, Gr.T. Popa University of Medicine and Pharmacy Iaşi.
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