| Total antioxidant capacity of diet in relation to cognitive function and decline. | |
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MedLine Citation:
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PMID: 20826624 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Epidemiologic evidence on the association of individual antioxidant vitamins and cognition is inconsistent. OBJECTIVE: We evaluated the total antioxidant capacity of diets on the basis of the ferric-reducing antioxidant power (FRAP) assay in relation to cognition in older women. DESIGN: Starting in 1995, we used a telephone-based cognitive assessment to evaluate cognitive function on 3 occasions at 2-y intervals in 16,010 participants aged ≥70 y in the Nurses' Health Study. In 1980, and every 4 y thereafter, we collected dietary information by using a semiquantitative food-frequency questionnaire (FFQ). For each participant, we combined FFQ data with food- and supplement-specific FRAP values to obtain FRAP scores; these data were averaged from 1980 until the initial cognitive interview to reflect long-term diets. We used multivariable-adjusted linear regression to estimate mean differences in initial cognitive function and slopes of decline across quintiles of FRAP scores. RESULTS: In multivariable-adjusted models, there was an association between higher total FRAP scores and better cognitive function at the first interview (P for trend = 0.003 for global scores with all cognitive tests combined; mean difference = 0.04 standard units; 95% CI: 0.01, 0.08 standard units, comparing the highest and lowest quintiles). A weaker association was observed for dietary FRAP scores (excluding supplements) and initial global scores (P for trend = 0.05). However, prospective analyses of cognitive decline indicated no associations with total or dietary FRAP scores in models adjusted for multiple potential confounders (P for trend = 0.3 and 0.5 for global scores, respectively). CONCLUSION: We observed no clear evidence of a consistent association between the total antioxidant capacity of diets and cognition in this cohort of older women. |
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Authors:
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Elizabeth E Devore; Jae Hee Kang; Meir J Stampfer; Francine Grodstein |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-09-08 |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 92 ISSN: 1938-3207 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-21 Completed Date: 2010-11-09 Revised Date: 2011-11-01 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 1157-64 Citation Subset: AIM; IM |
Affiliation:
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Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. edevore@partners.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antioxidants / pharmacology* Cognition / drug effects* Cognition Disorders* / prevention & control Diet* Female Humans Multivariate Analysis Prospective Studies Questionnaires Regression Analysis |
| Grant Support | |
ID/Acronym/Agency:
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AG15424/AG/NIA NIH HHS; CA40356/CA/NCI NIH HHS; F32 AG031633/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants |
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