Document Detail

Total antioxidant capacity of arginine-conjugated linoleic acid (CLA) complex.
MedLine Citation:
PMID:  14759129     Owner:  NLM     Status:  MEDLINE    
Conjugated linoleic acids (CLA) have shown diverse biological activities, including anti-carcinogenic, anti-atherosclerotic, anti-adipogenic, and anti-diabetogenic effects. Recent reports also showed that CLA has free radical scavenging capacity, which may give health benefits to human beings. However, the application of CLA as a bioactive ingredient has been limited due to its insolubility in water. To overcome this problem, we investigated antioxidant activities of arginine (Arg)-CLA, a water-soluble CLA salt, using both 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and 2,2'-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assays. CLA, Arg, and Arg-CLA all exerted radical scavenging activities in a dose-dependent manner in both assays. Arg-CLA at 20 mM scavenged 89 and 55% of ABTS and DPPH radicals in 3 h, respectively, whereas CLA alone quenched only 48 and 26% of them under the same conditions. The antioxidant activity of the Arg-CLA complex was found to be synergistic in ABTS assay and comparable to that of vitamin E in DPPH assay.
Young Jun Kim; Ki Won Lee; Hyong Joo Lee
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  52     ISSN:  0021-8561     ISO Abbreviation:  J. Agric. Food Chem.     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-02-04     Completed Date:  2004-03-17     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  439-44     Citation Subset:  IM    
Department of Molecular Biology and Genetics, Cornell University, New York, Ithaca 14853, USA.
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MeSH Terms
Antioxidants / pharmacology*
Arginine / analogs & derivatives*,  pharmacology
Biphenyl Compounds
Free Radical Scavengers
Linoleic Acids, Conjugated / chemistry,  pharmacology*
Sulfonic Acids
Reg. No./Substance:
0/Antioxidants; 0/Benzothiazoles; 0/Biphenyl Compounds; 0/Free Radical Scavengers; 0/Linoleic Acids, Conjugated; 0/Picrates; 0/Sulfonic Acids; 1898-66-4/2,2-diphenyl-1-picrylhydrazyl; 28752-68-3/2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid; 74-79-3/Arginine; 7732-18-5/Water

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