Document Detail


Total and allergen-specific immunoglobulin A levels in saliva in relation to the development of allergy in infants up to 2 years of age.
MedLine Citation:
PMID:  12220466     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The association between salivary IgA levels and development of allergy is controversial and the employed methodology has been questioned. OBJECTIVE: The aim of the study was to relate the levels of total IgA, SIgA and allergen-specific IgA antibodies in saliva to the development of allergy in infants during the first 2 years of life. METHODS: Saliva samples from 80 infants participating in a prospective study regarding the development of allergy were collected at 3 or 6, and 12 and 24 months of age. Total IgA, SIgA and Fel d 1 and beta-lactoglobulin specific IgA levels were analysed with ELISA. RESULTS: The levels of total IgA and SIgA increased with age. The number of samples with detectable IgA to Fel d 1 tended to increase with age, whereas the opposite was observed for IgA to beta-lactoglobulin. Infants who developed allergy tended to have higher levels of total IgA, and allergen-specific IgA was more commonly detected than in non-allergic children. In contrast, non-allergic children tended to have higher levels of SIgA. Furthermore, the levels of SIgA were higher in sensitized infants with no allergic symptoms than in sensitized children with symptoms. Infants with allergic parents had lower SIgA levels than infants without. Direct exposure to cat and cow's milk did not influence the levels of allergen-specific IgA levels, nor was there any association between breast-feeding and IgA production. CONCLUSION: The kinetics of food and inhalant allergen-specific IgA in saliva during the first 2 years of life is similar to what has earlier been shown for IgG in serum. Development of allergy tended to be associated with high levels of total and allergen-specific IgA antibodies, but low levels of SIgA. Furthermore, high levels of SIgA seemed to protect sensitized children from developing allergic symptoms during the first 2 years of life, supporting a possible protective role of SIgA against development of allergy.
Authors:
M F Böttcher; P Häggström; B Björkstén; M C Jenmalm
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology     Volume:  32     ISSN:  0954-7894     ISO Abbreviation:  Clin. Exp. Allergy     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-09-10     Completed Date:  2003-03-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8906443     Medline TA:  Clin Exp Allergy     Country:  England    
Other Details:
Languages:  eng     Pagination:  1293-8     Citation Subset:  IM    
Affiliation:
Department of Molecular and Clinical Medicine, Division of Paediatrics, and Clinical Research Centre, Faculty of Health Sciences, Linköping University, Sweden. malfa@kfc.liu.se
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MeSH Terms
Descriptor/Qualifier:
Allergens / immunology
Antibodies / immunology
Antibody Specificity
Child, Preschool
Enzyme-Linked Immunosorbent Assay / methods
Humans
Hypersensitivity, Immediate / immunology*
Immunoglobulin A / analysis*
Immunoglobulin A, Secretory / analysis
Infant
Prospective Studies
Saliva / immunology*
Skin Tests
Statistics, Nonparametric
Chemical
Reg. No./Substance:
0/Allergens; 0/Antibodies; 0/Immunoglobulin A; 0/Immunoglobulin A, Secretory

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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