Document Detail

Total and active ghrelin in developing rats during hypoxia.
MedLine Citation:
PMID:  12897380     Owner:  NLM     Status:  MEDLINE    
Hypoxia is well known to decrease appetite and weight gain in growing rats, and to induce weight loss in humans. It has been hypothesized that this is mediated by a change in ghrelin, an orexigenic peptide synthesized and released primarily from the stomach. Rats were exposed to hypoxia for 7 d as neonates (birth-7 d of age), weanlings (28-35 d of age), and juveniles (49-56 d of age). Hypoxia had no effect on total or active plasma ghrelin. There was a significant decrease in active ghrelin in weaned rats (0.8 +/- 0.1 ng/mL) compared to nursing pups at 7 d of age (2.3 +/- 0.2 ng/mL). The proportion of total ghrelin that was active decreased significantly between 7 and 35 d of age. We conclude that the anorexia and weight loss associated with hypoxia is probably not mediated by ghrelin. There appear to be changes in active ghrelin levels in plasma during early development in the rat.
Hershel Raff
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Endocrine     Volume:  21     ISSN:  1355-008X     ISO Abbreviation:  Endocrine     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-08-04     Completed Date:  2004-04-13     Revised Date:  2010-06-24    
Medline Journal Info:
Nlm Unique ID:  9434444     Medline TA:  Endocrine     Country:  United States    
Other Details:
Languages:  eng     Pagination:  159-61     Citation Subset:  IM    
Endocrine Research Laboratory, St. Luke's Medical Center, Medical College of Wisconsin, Milwaukee, WI 53215, USA.
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MeSH Terms
Aging / metabolism*
Animals, Newborn / metabolism
Animals, Suckling / metabolism
Anoxia / metabolism*
Body Weight / physiology*
Eating / physiology*
Peptide Hormones / blood*
Peptides / blood
Rats, Sprague-Dawley
Weight Loss / physiology
Reg. No./Substance:
0/Ghrelin; 0/Peptide Hormones; 0/Peptides; 0/ghrelin, des-n-octanoyl

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