Document Detail

Total absence of eosinophils in a patient with an allergic disorder.
MedLine Citation:
PMID:  6784627     Owner:  NLM     Status:  MEDLINE    
A 45-year-old woman with a 25-year history of episodic urticaria and rhinitis had no detectable eosinophils in blood or bone marrow; levels of other leukocytes were normal. No eosinophils were found in the nasal discharge or the exudate elicited in skin windows by ragweed extract, to which the patient exhibited an immediate-type hypersensitivity response. A complement-dependent IgG-related activity in the patient's serum cytotoxically degranulated human eosinophils in vitro without affecting neutrophils. Antieosinophil activity was confirmed by the ability of a single dose of the patient's serum to suppress significantly the eosinophil counts in monkeys for up to 12 hours. This is the first description of an isolated absence of eosinophils, a condition that may present with allergic manifestations.
W Franklin; E J Goetzl
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Annals of internal medicine     Volume:  94     ISSN:  0003-4819     ISO Abbreviation:  Ann. Intern. Med.     Publication Date:  1981 Mar 
Date Detail:
Created Date:  1981-06-13     Completed Date:  1981-06-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372351     Medline TA:  Ann Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  352-3     Citation Subset:  AIM; IM    
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MeSH Terms
Bone Marrow / pathology
Cells, Cultured
Complement System Proteins / pharmacology
Eosinophils / immunology*
Hypersensitivity / immunology*
Immunoglobulin G / immunology
Leukocyte Count
Time Factors
Grant Support
Reg. No./Substance:
0/Immunoglobulin G; 9007-36-7/Complement System Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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