| Total Synthesis and Biological Evaluation of (-)-9-Deoxy-englerin A. | |
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MedLine Citation:
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PMID: 21413694 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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An effective total synthesis of (-)-9-deoxy-englerin (4), an analogue of the natural guaiane sesquiterpene englerin A (1), has been achieved. The synthesis features a transannular epoxide opening to construct the 5,7-fused ring system followed by transannular ether formation with mercury(II) trifluoroacetate. |
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Authors:
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Dmitry B Ushakov; Vaidotas Navickas; Markus Ströbele; Cäcilia Maichle-Mössmer; Florenz Sasse; Martin E Maier |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-17 |
Journal Detail:
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Title: Organic letters Volume: - ISSN: 1523-7052 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100890393 Medline TA: Org Lett Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Institut für Organische Chemie, Universität Tübingen, Auf der Morgenstelle 18, 72076 Tübingen, Germany, Abteilung für Festkörperchemie und Theoretische Anorganische Chemie, Institut für Anorganische Chemie, Universität Tübingen, Ob dem Himmelreich 7, 72074 Tübingen, Germany, Institut für Anorganische Chemie, Universität Tübingen, Auf der Morgenstelle 18, 72076 Tübingen, Germany, and Abteilung Chemische Biologie, Helmholtz-Zentrum für Infektionsforschung, Inhoffenstrasse 7, 38124 Braunschweig, Germany. |
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