Document Detail

Total Sleep Deprivation Augments Balloon Angioplasty-Induced Neointimal Hyperplasia in Rat.
MedLine Citation:
PMID:  21841036     Owner:  NLM     Status:  Publisher    
Sleep deprivation has been shown to be associated with an increase in inflammation that also involved in the development of neointimal hyperplasia (or restenosis). The purpose of this study was to investigate whether total sleep deprivation (TSD) will worsen neointimal formation by balloon injury. Sixteen rats were randomly allocated into four groups: Group 1, balloon angioplasty alone; Group 2, TSD prior to angioplasty; Group 3, angioplasty before TSD; Group 4, TSD before and after angioplasty. TSD was induced by the disc-on-water method, and balloon angioplasty was performed in rat carotid artery. The histopathological analysis and cytokines assay were applied to evaluate the effects of TSD in this study. TSD significantly increased the ratio of post-injury neointima-to-media area in Group 2 (p < 0.01), Group 3 (p < 0.01) and Group 4 (p < 0.01) as compared with those of Group 1. Additionally, all groups of TSD administration also markedly decreased the serum level of interleukin-10 (IL-10) at day 3 after angioplasty injury (p < 0.05 or p < 0.01). Our preliminary finding suggested that perioperative TSD can significantly augment neointimal hyperplasia of carotid artery in rats, which may be partially caused by TSD-induced effect in suppressing the serum level of anti-inflammatory cytokine, IL-10.
Sai-Chuen Rick Wu; Chiu-Chen Huang; Chun-Hsu Pan; King-Chuen Wu; Chia-Chen Chen; Shih-Kai Liu; Chien-Lun Tang; Chieh-Hsi Wu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-12
Journal Detail:
Title:  Experimental physiology     Volume:  -     ISSN:  1469-445X     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-8-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9002940     Medline TA:  Exp Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1 China Medical University Hospital;
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