Document Detail

Total ischemic time: the correct focus of attention for optimal ST-segment elevation myocardial infarction care.
MedLine Citation:
PMID:  21700244     Owner:  NLM     Status:  MEDLINE    
Currently accepted standards for gauging quality of care in the treatment of ST-segment elevation myocardial infarction (STEMI) mainly focus on shortening the time to treatment after the patient arrives at the hospital. But this narrow focus fails to consider the substantial duration of myocardial ischemia that exists prior to hospital arrival, and the large number of deaths that occur during the pre-hospital period. The time from symptom onset until reperfusion occurs is one estimate of total ischemic time. Several experimental studies and now human clinical studies have confirmed that infarct size and mortality are strongly correlated with the total ischemic time, and much less so with its subintervals like door-to-balloon time. This review will discuss the importance of total ischemic time in STEMI.
Ali E Denktas; H Vernon Anderson; James McCarthy; Richard W Smalling
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  JACC. Cardiovascular interventions     Volume:  4     ISSN:  1876-7605     ISO Abbreviation:  JACC Cardiovasc Interv     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-06-24     Completed Date:  2011-11-10     Revised Date:  2014-09-05    
Medline Journal Info:
Nlm Unique ID:  101467004     Medline TA:  JACC Cardiovasc Interv     Country:  United States    
Other Details:
Languages:  eng     Pagination:  599-604     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Angioplasty, Balloon*
Confidence Intervals
Emergency Medical Services*
Fibrinolytic Agents / adverse effects,  therapeutic use*
Health Services Accessibility
Health Services Needs and Demand
Magnetic Resonance Imaging
Myocardial Infarction / drug therapy*,  pathology,  therapy
Myocardial Ischemia / drug therapy*,  pathology,  therapy
Myocardial Reperfusion / methods*
Odds Ratio
Reg. No./Substance:
0/Fibrinolytic Agents
Comment In:
JACC Cardiovasc Interv. 2011 Sep;4(9):1051; author reply 1051-1052   [PMID:  21939950 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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