Document Detail

Total enteral nutrition in prevention of pancreatic necrotic infection in severe acute pancreatitis.
MedLine Citation:
PMID:  19910834     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: This study was designed to evaluate the effects of total enteral nutrition and total parenteral nutrition in prevention of pancreatic necrotic infection in severe acute pancreatitis. METHODS: One hundred seven patients were enrolled in the study between 2003 and 2007. In the first week of hospitalization, they were randomized to feeding by either total parenteral nutrition (54 patients) or total enteral nutrition (53 patients). All patients were concomitantly administered with sufficient prophylactic antibiotics. Computed tomographic scan and C-reactive protein level indicated a similar clinical severity in both groups. RESULTS: Eighty percent of the patients developed organ failure in the group with total parenteral nutrition, which was higher than that in the group with total enteral nutrition (21%). Eighty percent and 22% (P < 0.05) of the patients in the total parenteral nutrition and total enteral nutrition groups, respectively, underwent surgical intervention. The incidence of pancreatic septic necroses in the group with total enteral nutrition (23%) was lower than that in the group with total parenteral nutrition (72%, P < 0.05). Mortality in the total parenteral nutrition group (43%) was higher than in the total enteral nutrition group (11%, P < 0.05). CONCLUSION: Total enteral nutrition is better than total parenteral nutrition in the prevention of pancreatic necrotic infection in severe acute pancreatitis.
Xing-Mao Wu; Kai-Qiang Ji; Hai-Yuan Wang; Guo-Fu Li; Bin Zang; Wei-Min Chen
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Pancreas     Volume:  39     ISSN:  1536-4828     ISO Abbreviation:  Pancreas     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-25     Completed Date:  2010-05-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8608542     Medline TA:  Pancreas     Country:  United States    
Other Details:
Languages:  eng     Pagination:  248-51     Citation Subset:  IM    
Intensive Care Unit, Shengjing Hospital, China Medical University, Shenyang, Liaoning Province, China.
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MeSH Terms
Anti-Bacterial Agents / therapeutic use
Bacterial Infections / microbiology,  mortality,  pathology,  prevention & control*
Biological Markers / blood
C-Reactive Protein / metabolism
Chi-Square Distribution
Enteral Nutrition* / adverse effects,  mortality
Middle Aged
Multiple Organ Failure / microbiology,  prevention & control
Pancreatitis, Acute Necrotizing / complications,  diagnosis,  mortality,  surgery,  therapy*
Parenteral Nutrition, Total* / adverse effects,  mortality
Pneumonia, Aspiration / microbiology,  prevention & control
Severity of Illness Index
Shock, Septic / microbiology,  prevention & control
Time Factors
Tomography, Spiral Computed
Treatment Outcome
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Biological Markers; 9007-41-4/C-Reactive Protein

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