Document Detail

Torsional and Lateral Resonant Modes of Cantilevers as Biosensors: Alternatives to Bending Modes.
MedLine Citation:
PMID:  23276186     Owner:  NLM     Status:  Publisher    
We show novel cantilever designs that express torsional and lateral modes exhibit excellent mass-change sensitivity to molecular self-assembly on gold (75 - 135 fg/Hz ) which is superior to that of widely investigated bending modes. Lead zirconate titanate (PZT) millimeter-sized cantilevers were designed with two types of anchor asymmetry that induced expression of either torsional or lateral modes in the 0 - 80 kHz frequency range. Experiments and supporting calculations show that anchor asymmetry enables resonant mode impedance-coupling. The sensitive torsional and lateral modes enabled measurement of self-assembled monolayer formation rate at picomolar levels. The anchor design principle was extended to micro-cantilevers via finite element simulations, which caused both 97% sensitivity improvement relative to conventional designs as well as new non-classical resonant mode shapes.
Blake N Johnson; Harsh Sharma; Raj Mutharasan
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-31
Journal Detail:
Title:  Analytical chemistry     Volume:  -     ISSN:  1520-6882     ISO Abbreviation:  Anal. Chem.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2013-1-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370536     Medline TA:  Anal Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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