Document Detail


Torsades de pointes in a case of hypertrophic cardiomyopathy with special reference to the pathologic findings of the heart including the conduction system.
MedLine Citation:
PMID:  10420884     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A clinicopathologic study was performed in a 77-year-old female with hypertrophic cardiomyopathy who had experienced recurrent syncopal attacks due to Torsades de Pointes (TdP) following QT prolongation and atrioventricular block. She died suddenly two years later while eating dinner. Pathologic findings of the heart showed a dilated and hypertrophied left ventricle. The heart weighed 550 g. There were two foci of localized endocardial fibroelastosis (EFE) beneath the aortic valve, one with a size of 3.5 x 3.5 cm, and the other (2 x 1 cm) located on the upper ventricular septum. Histologic findings showed hypertrophy and disarray in the left ventricular myocardium. The conduction system using serial sectioning revealed remarkable bilateral bundle branch fibrosis and hypertrophied Purkinje fibers in the left bundle branch adjacent to the EFE on the ventricular septum. These findings were thought to be related to the occurrence of TdP.
Authors:
K Kuboki; S Ohkawa; K Chida; C Watanabe; K Ueda; M Sugiura
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Japanese heart journal     Volume:  40     ISSN:  0021-4868     ISO Abbreviation:  Jpn Heart J     Publication Date:  1999 Mar 
Date Detail:
Created Date:  1999-08-05     Completed Date:  1999-08-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0401175     Medline TA:  Jpn Heart J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  233-8     Citation Subset:  IM    
Affiliation:
Division of Cardiology, Tokyo Metropolitan Geriatric Hospital, Japan.
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MeSH Terms
Descriptor/Qualifier:
Aged
Cardiomyopathy, Hypertrophic / complications,  pathology*,  physiopathology
Death, Sudden, Cardiac*
Electrocardiography
Female
Heart Conduction System / pathology*,  physiopathology
Humans
Hypertrophy, Left Ventricular / complications,  pathology*,  physiopathology
Torsades de Pointes / etiology,  pathology*,  physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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