Document Detail


Torsade de pointes and other pause-induced ventricular tachycardias: the short-long-short sequence and early afterdepolarizations.
MedLine Citation:
PMID:  2456546     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The early afterdepolarization, which is an interruption of repolarization, can evoke a second upstroke or a salvo of action potentials. It is suggested that the electrophysiological characteristics of the early afterdepolarization can produce a lengthening of the QT interval and that the second upstroke and salvo of activity that may follow, it can explain many features of torsade de pointes and of certain other ventricular tachycardias. The early afterdepolarization, torsade de pointes, and repetitive monomorphic idiopathic ventricular tachycardia are all induced by bradycardia or by a preceding long RR interal. The R-on-T phenomenon is also discussed.
Authors:
P F Cranefield; R S Aronson
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pacing and clinical electrophysiology : PACE     Volume:  11     ISSN:  0147-8389     ISO Abbreviation:  Pacing Clin Electrophysiol     Publication Date:  1988 Jun 
Date Detail:
Created Date:  1988-08-26     Completed Date:  1988-08-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7803944     Medline TA:  Pacing Clin Electrophysiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  670-8     Citation Subset:  IM    
Affiliation:
Laboratory of Cardiac Physiology, Rockefeller University, New York, N.Y.
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MeSH Terms
Descriptor/Qualifier:
Animals
Dogs
Electrocardiography
Heart Conduction System / physiopathology*
Humans
Long QT Syndrome / physiopathology
Tachycardia / physiopathology*
Time Factors
Grant Support
ID/Acronym/Agency:
HL-14899/HL/NHLBI NIH HHS; HL-32688/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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