| Torsade-de-pointes in a patient under flecainide treatment, an unusual case of proarrhythmicity. | |
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MedLine Citation:
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PMID: 17056139 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Flecainide is an antiarrhythmic considered safe in patients who have no structural cardiopathy, and frequently used in the prevention of atrial fibrillation. However, in patients with a history of infarction and/or severe conduction disorders, its proarrhythmicity may be lethal. Torsade-de-pointes type tachycardia is not included as one of these proarrhythmic effects, since the drug's scant action on ventricular repolarization makes this adverse effect very unlikely. We present the case of a patient who, shortly after beginning treatment with flecainide, was admitted because of syncope related to bradyarrhythmias, long QT, and torsade-de-pointes. There have been very few published cases in which one finds such an association between flecainide and this infrequent arrhythmia. |
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Authors:
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Juan M Nogales Asensio; Nieves Moreno Sánchez; Luis Javier Doncel Vecino; Celia Villar Mariscal; Jose R López-Mínguez; Antonio Merchán Herrera |
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Publication Detail:
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Type: Case Reports; Letter Date: 2006-10-23 |
Journal Detail:
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Title: International journal of cardiology Volume: 114 ISSN: 1874-1754 ISO Abbreviation: Int. J. Cardiol. Publication Date: 2007 Jan |
Date Detail:
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Created Date: 2006-11-27 Completed Date: 2007-01-25 Revised Date: 2007-02-22 |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: E65-7 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Anti-Arrhythmia Agents / adverse effects* Female Flecainide / adverse effects* Humans Torsades de Pointes / chemically induced* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Arrhythmia Agents; 54143-55-4/Flecainide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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