Document Detail


Toremifene increases the expression of intercellular adhesion molecule-1 (ICAM-1) on MCF-7 breast cancer cells and Jurkat cells.
MedLine Citation:
PMID:  10632979     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study was conducted to reveal the effect of the nonsteroidal anti-oestrogen toremifene on the expression of cell-surface molecules involved in the immunogenicity of tumours or the sensitivity of tumour cells to apoptotic cell death. We studied the effect of toremifene on the expression of HLA-DR, ICAM-1, costimulatory molecules CD80 and CD86, and the tumour necrosis factor receptor (TNF-R) family molecules CD27, CD30, CD40, TNF-R1, TNF-R2 and Fas (CD95) on MCF-7 breast cancer and Jurkat T cells. In addition, the effect of toremifene on Fas-mediated apoptosis was studied. Toremifene did not affect Fas expression or Fas-mediated apoptosis in Fas-resistant MCF-7 or Fas-sensitive Jurkat cells, but was found to increase the expression of ICAM-1 in both cell lines. In addition, toremifene increased the expression of CD40 and CD80 on MCF-7 cells. The expression of ICAM-1 in tumours plays an important role in the interaction of tumour cells and effector cells of the immune system. Therefore, we suggest that toremifene may modulate the immunogenicity of tumour cells by increasing the expression of ICAM-1.
Authors:
J Komi; O Lassila
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of immunology     Volume:  51     ISSN:  0300-9475     ISO Abbreviation:  Scand. J. Immunol.     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-03-07     Completed Date:  2000-03-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0323767     Medline TA:  Scand J Immunol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  73-8     Citation Subset:  IM    
Affiliation:
Turku Immunology Centre, Department of Medical Microbiology, Turku University, Turku, Finland.
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MeSH Terms
Descriptor/Qualifier:
Antigens, CD40 / metabolism
Antigens, CD80 / metabolism
Antigens, CD95 / metabolism
Antineoplastic Agents, Hormonal / pharmacology*
Apoptosis / drug effects
Breast Neoplasms / drug therapy*,  immunology*,  pathology
Daunorubicin / pharmacology
Female
HLA-DR Antigens / metabolism
Humans
Intercellular Adhesion Molecule-1 / metabolism*
Interferon-gamma, Recombinant / pharmacology
Jurkat Cells
Selective Estrogen Receptor Modulators / pharmacology*
Toremifene / pharmacology*
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
0/Antigens, CD40; 0/Antigens, CD80; 0/Antigens, CD95; 0/Antineoplastic Agents, Hormonal; 0/HLA-DR Antigens; 0/Interferon-gamma, Recombinant; 0/Selective Estrogen Receptor Modulators; 126547-89-5/Intercellular Adhesion Molecule-1; 20830-81-3/Daunorubicin; 89778-26-7/Toremifene

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