Document Detail


Topsy turvy: functions of climbing and mossy fibers in the vestibulo-cerebellum.
MedLine Citation:
PMID:  21362689     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The cerebellum's role in sensory-motor control and adaptation is undisputed. However, a key hypothesis pertaining to the function of cerebellar circuitry lacks experimental support. It is universally assumed that the discharge of mossy fibers accounts for modulation of Purkinje cell "simple spikes" (SSs). This assumption acts as a prism through which all other functions of cerebellar circuitry are viewed. The vestibulo-cerebellum (nodulus and uvula) receives a large, unilateral, vestibular primary afferent mossy fiber projection. We can test its role in modulating Purkinje cell SSs by recording the modulated activity of both mossy fiber terminals and Purkinje cell SSs evoked by identical natural vestibular stimulation. Sinusoidal rotation about the longitudinal axis (roll) modulates the activity of vestibular primary afferent mossy and climbing fibers as well as Purkinje cell SSs and complex spikes (CSs). Remarkably, vestibular primary afferent mossy fibers discharge 180 degrees out of phase with SSs. This indicates that mossy fibers cannot account for SS modulation unless an inhibitory synapse is interposed between mossy fibers or vestibular climbing fibers and Purkinje cells. The authors review several experiments that address the relative contributions of mossy and climbing fiber afferents to the modulation of SSs. They conclude that climbing fibers, not mossy fibers, are primarily responsible for the modulation of SSs as well as CSs and they propose revised functions for these two afferent systems.
Authors:
Neal H Barmack; Vadim Yakhnitsa
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2011-02-28
Journal Detail:
Title:  The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry     Volume:  17     ISSN:  1089-4098     ISO Abbreviation:  Neuroscientist     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-04-14     Completed Date:  2011-08-04     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  9504819     Medline TA:  Neuroscientist     Country:  United States    
Other Details:
Languages:  eng     Pagination:  221-36     Citation Subset:  IM    
Affiliation:
Department of Physiology & Pharmacology, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA. barmackn@ohsu.edu
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MeSH Terms
Descriptor/Qualifier:
Action Potentials / physiology
Animals
Cerebellum / cytology*,  physiology*
Humans
Nerve Fibers / physiology*
Nerve Net / physiology
Neural Pathways / physiology
Purkinje Cells / physiology*
Vestibule, Labyrinth / physiology*
Grant Support
ID/Acronym/Agency:
DC006668/DC/NIDCD NIH HHS; EY018561/EY/NEI NIH HHS; R01 DC006668-08/DC/NIDCD NIH HHS; R01 EY018561-05/EY/NEI NIH HHS
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