Document Detail


Topography of brain damage in metabolic hypoglycaemia is determined by age at which hypoglycaemia occurred.
MedLine Citation:
PMID:  23205874     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Aim  Having previously shown that comorbidity is a major determinant of neurological sequelae in hypoglycaemia, our aim was to describe the neuroimaging patterns of brain damage in different hypoglycaemic situations and to elucidate the factors that determine lesion topography. Method  We reviewed 50 patients (31 females, 19 males) with symptomatic hypoglycaemia (<2.8mmol/L) occurring between 1 day and 5 years of age (median 4d) who had undergone magnetic resonance imaging (MRI; at least axial T2-weighted, sagittal T1-weighted, and coronal fluid-attenuated inversion recovery [FLAIR]-weighted imaging). MRI was performed during the follow-up examination at least 1 month after the occurrence of symptomatic hypoglycaemia, i.e. between 1 month and 5 years of age (median 3mo). Hypoglycaemia resulted from three inborn errors of metabolism: congenital hyperinsulinism (33 patients), fatty acid β-oxidation disorders (13 patients), or glycogen storage disease type I (four patients). We selected the patients with clear MRI abnormalities and analysed their topography according to aetiology and age at occurrence of the lesion. Results  The topography of the brain lesions depended on age: from the neonatal period to 6 months of age, lesions predominantly involved the posterior white matter; between 6 and 22 months the basal ganglia, and after 22 months the parietotemporal cortex (p=0.04). Interpretation  The relationship between brain lesions and age could reflect the maturation sequence of the brain.
Authors:
Svetlana Gataullina; Pascale DE Lonlay; Georges Dellatolas; Vassili Valayannapoulos; Silvia Napuri; Léna Damaj; Guy Touati; Cecila Altuzarra; Olivier Dulac; Nathalie Boddaert
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-4
Journal Detail:
Title:  Developmental medicine and child neurology     Volume:  -     ISSN:  1469-8749     ISO Abbreviation:  Dev Med Child Neurol     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0006761     Medline TA:  Dev Med Child Neurol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© The Authors. Developmental Medicine & Child Neurology © 2012 Mac Keith Press.
Affiliation:
 Neuropediatrics Department, Necker-Enfants Malades Hospital, AP-HP, Paris;  Centre for Inherited Metabolic Disorders, Necker-Enfants Malades Hospital AP-HP, Université Paris Descartes, Paris;  Inserm U669, Université Paris Descartes, Université Paris-Sud, Paris;  Reference Centre for Inherited Metabolic Disorders, Necker-Enfants Malades Hospital AP-HP, Paris;  Paediatric Department, CHU Hôpital Sud, Rennes;  Paediatric Department, CHU Hôpital Saint-Jacques, Besançon;  INSERM UMR663, Université Paris Descartes, Paris;  Radiologic Department, Necker-Enfants Malades Hospital, AP-HP, Université Paris Descartes, Paris, France.
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