Document Detail


Topographical specialization of prostaglandin function in late pregnancy and at parturition in the baboon.
MedLine Citation:
PMID:  14683693     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Prostaglandins play key central roles in both the maintenance of pregnancy and parturition. Extensive data exist from studies in human pregnancy but the needs of clinical management and the inability to conduct carefully controlled perturbation studies in human pregnancy make it necessary to obtain information from nonhuman primate models. We have used the pregnant baboon to evaluate production, metabolism and receptor mediated actions of prostaglandins in late gestation to demonstrate that expression of key genes is tightly controlled in enzyme-specific, gestation age-specific, tissue-specific and uterine region-specific fashion.
Authors:
Peter W Nathanielsz; Gordon Smith; Wen Wu
Related Documents :
21533533 - Papp-a levels of late pregnancy in preeclampsia and hellp syndrome.
7408783 - The effect of estrogen on fetal survival in progesterone-treated ovariectomized rats.
8158613 - Seasonal occurrence and reproductive status of opisocrostis bruneri (siphonaptera: cera...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Prostaglandins, leukotrienes, and essential fatty acids     Volume:  70     ISSN:  0952-3278     ISO Abbreviation:  Prostaglandins Leukot. Essent. Fatty Acids     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2003-12-19     Completed Date:  2004-08-17     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  8802730     Medline TA:  Prostaglandins Leukot Essent Fatty Acids     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  199-206     Citation Subset:  IM    
Affiliation:
Department of Obstetrics, Center for Women's Health Research, New York University Medical School, 550 1st Ave, New York 10016, USA. peter.nathanielsz@med.nyu.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Arachidonic Acid / metabolism
Decidua / metabolism
Extraembryonic Membranes / metabolism
Female
Gene Expression
Humans
Hydroxyprostaglandin Dehydrogenases / metabolism
Papio
Parturition / metabolism*,  physiology
Pregnancy / metabolism,  physiology
Pregnancy, Animal / metabolism*,  physiology,  psychology
Prostaglandin-Endoperoxide Synthases / metabolism
Prostaglandins / metabolism*,  physiology
Receptors, Prostaglandin / metabolism
Signal Transduction / physiology
Uterus / anatomy & histology,  metabolism*,  physiology
Chemical
Reg. No./Substance:
0/Prostaglandins; 0/Receptors, Prostaglandin; 506-32-1/Arachidonic Acid; EC 1.1.1.-/Hydroxyprostaglandin Dehydrogenases; EC 1.14.99.1/Prostaglandin-Endoperoxide Synthases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Cannabis, cannabinoids and reproduction.
Next Document:  Prostaglandins and the myometrium and cervix.