Document Detail

Topographical specialization of prostaglandin function in late pregnancy and at parturition in the baboon.
MedLine Citation:
PMID:  14683693     Owner:  NLM     Status:  MEDLINE    
Prostaglandins play key central roles in both the maintenance of pregnancy and parturition. Extensive data exist from studies in human pregnancy but the needs of clinical management and the inability to conduct carefully controlled perturbation studies in human pregnancy make it necessary to obtain information from nonhuman primate models. We have used the pregnant baboon to evaluate production, metabolism and receptor mediated actions of prostaglandins in late gestation to demonstrate that expression of key genes is tightly controlled in enzyme-specific, gestation age-specific, tissue-specific and uterine region-specific fashion.
Peter W Nathanielsz; Gordon Smith; Wen Wu
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Prostaglandins, leukotrienes, and essential fatty acids     Volume:  70     ISSN:  0952-3278     ISO Abbreviation:  Prostaglandins Leukot. Essent. Fatty Acids     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2003-12-19     Completed Date:  2004-08-17     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  8802730     Medline TA:  Prostaglandins Leukot Essent Fatty Acids     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  199-206     Citation Subset:  IM    
Department of Obstetrics, Center for Women's Health Research, New York University Medical School, 550 1st Ave, New York 10016, USA.
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MeSH Terms
Arachidonic Acid / metabolism
Decidua / metabolism
Extraembryonic Membranes / metabolism
Gene Expression
Hydroxyprostaglandin Dehydrogenases / metabolism
Parturition / metabolism*,  physiology
Pregnancy / metabolism,  physiology
Pregnancy, Animal / metabolism*,  physiology,  psychology
Prostaglandin-Endoperoxide Synthases / metabolism
Prostaglandins / metabolism*,  physiology
Receptors, Prostaglandin / metabolism
Signal Transduction / physiology
Uterus / anatomy & histology,  metabolism*,  physiology
Reg. No./Substance:
0/Prostaglandins; 0/Receptors, Prostaglandin; 506-32-1/Arachidonic Acid; EC 1.1.1.-/Hydroxyprostaglandin Dehydrogenases; EC Synthases

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