Document Detail


Topographical localization of lipofuscin pigment in the brain of the aged fat-tailed dwarf lemur (Cheirogaleus medius) and grey lesser mouse lemur (Microcebus murinus): comparison to iron localization.
MedLine Citation:
PMID:  10466576     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study was undertaken to explore the distribution of lipofuscin in the brain of cheirogaleids by autofluorescence and compare it to other studies of iron distribution. Aged dwarf (Cheirogaleus medius) and mouse (Microcebus murinus) lemurs provide a reliable model for the study of normal and pathological cerebral aging. Accumulation of lipofuscin, an age pigment derived by lipid peroxidation, constitutes the most reliable cytological change correlated with neuronal aging. Brain sections of four aged (8-15 year old) and 3 young (2-3 year old) animals were examined. Lipofuscin accumulation was observed in the aged animals but not in the young ones. Affected regions include the hippocampus (granular and pyramidal cells), where no iron accumulation was observed, the olfactory nucleus and the olfactory bulb (mitral cells), the basal forebrain, the hypothalamus, the cerebellum (Purkinje cells), the neocortex (essentially in the pyramidal cells), and the brainstem. Even though iron is known to catalyse lipid oxidation, our data indicate that iron deposits and lipofuscin accumulation are not coincident. Different biochemical and morphological cellular compartments might be involved in iron and lipofuscin deposition. The nonuniform distribution of lipofuscin indicates that brain structures are not equally sensitive to the factors causing lipofuscin accumulation. The small size, the rapid maturity, and the relatively short life expectancy of the cheirogaleids make them a good model system in which to investigate the mechanisms of lipofuscinogenesis in primates.
Authors:
E P Gilissen; R E Jacobs; E R McGuinness; J M Allman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of primatology     Volume:  49     ISSN:  0275-2565     ISO Abbreviation:  Am. J. Primatol.     Publication Date:  1999 Oct 
Date Detail:
Created Date:  1999-10-14     Completed Date:  1999-10-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8108949     Medline TA:  Am J Primatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  183-93     Citation Subset:  IM    
Affiliation:
Division of Biology, California Institute of Technology, Pasadena, USA. 055ape@chiron.wits.ac.za
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / metabolism*
Cheirogaleidae / physiology*
Disease Models, Animal
Iron / analysis*,  pharmacokinetics
Lipofuscin / analysis*,  pharmacokinetics
Neurodegenerative Diseases / physiopathology*,  veterinary
Tissue Distribution
Chemical
Reg. No./Substance:
0/Lipofuscin; 7439-89-6/Iron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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