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Topographic variation of choroidal and retinal thicknesses at the macula in healthy adults.
MedLine Citation:
PMID:  24288389     Owner:  NLM     Status:  Publisher    
BACKGROUND/AIMS: To determine the topographic variation of macular choroidal and retinal thicknesses (RTs) in normal eyes and their relationship with refractive error.
METHODS: Spectral domain optical coherence tomography with enhanced depth imaging was performed on 124 healthy participants using a standardised imaging protocol. Manual segmentation of choroidal boundaries was performed by trained graders, and mean choroidal thickness (CT) was compared with mean RT in corresponding sectors of the Early Treatment Diabetic Retinopathy Study (ETDRS) grid.
RESULTS: Mean central subfield CT was 322.2 µm. The choroid was thickest at the temporal and superior sectors (323.1-338.1 µm), followed by inferior sectors (314.0-321.8 µm), and thinnest at the nasal sectors (232.8-287.8 µm). In contrast, the retina was thicker nasally (343.4 µm) and thinner temporally (287.1 µm). CT was thickest among emmetropes in all ETDRS subfields and became thinner progressively among low, moderate and high myopes (p<0.001). The variation of both choroidal and RTs among refractive error groups resulted in different topographic patterns at the macula.
CONCLUSION: There is significant topographic variation of choroidal and RTs at different regions of the macula, with progressive change of choroidal thickness in all sectors based on the refractive status of the eye.
Colin S H Tan; Kai Xiong Cheong; Louis W Lim; Kelvin Z Li
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-11-28
Journal Detail:
Title:  The British journal of ophthalmology     Volume:  -     ISSN:  1468-2079     ISO Abbreviation:  Br J Ophthalmol     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2013-11-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0421041     Medline TA:  Br J Ophthalmol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, Singapore.
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