Document Detail

Topographic analysis of cell proliferation in the hippocampus of the adult mouse.
MedLine Citation:
PMID:  16317349     Owner:  NLM     Status:  MEDLINE    
The dentate gyrus of the hippocampus generates new neurons throughout life. The distribution of neural progenitor cells in the hippocampus along the anteroposterior axis is, however, not known. To determine whether mitotic activity differs along the anteroposterior axis, we examined mitotic activity in serial hippocampal sections of two experimental groups: normal bred (control) and exercised groups. In both groups, the number of 5-bromo-2'-deoxyuridine-positive cells was markedly decreased in the caudal dentate gyrus; exercised groups also had mitotic activity of about 1.5 times that of control groups. Mitotic activity tended to increase in the suprapyramidal blade of the middle dentate gyrus of exercised groups. These results indicate that the adult hippocampus has regional differences in mitotic activity.
Katsuya Uchida; Souichiro Nakamura; Tetsuya Kobayashi; Takeo Machida
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuroreport     Volume:  16     ISSN:  0959-4965     ISO Abbreviation:  Neuroreport     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-11-30     Completed Date:  2006-02-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  England    
Other Details:
Languages:  eng     Pagination:  2033-6     Citation Subset:  IM    
Laboratory of Information Biology, Graduate School of Information Sciences, Tohoku University, Sendai, Japan.
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MeSH Terms
Cell Proliferation*
Hippocampus / cytology*
Mice, Inbred C57BL
Neurons / cytology*
Physical Conditioning, Animal / physiology

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