| Topographic analysis of cell proliferation in the hippocampus of the adult mouse. | |
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MedLine Citation:
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PMID: 16317349 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The dentate gyrus of the hippocampus generates new neurons throughout life. The distribution of neural progenitor cells in the hippocampus along the anteroposterior axis is, however, not known. To determine whether mitotic activity differs along the anteroposterior axis, we examined mitotic activity in serial hippocampal sections of two experimental groups: normal bred (control) and exercised groups. In both groups, the number of 5-bromo-2'-deoxyuridine-positive cells was markedly decreased in the caudal dentate gyrus; exercised groups also had mitotic activity of about 1.5 times that of control groups. Mitotic activity tended to increase in the suprapyramidal blade of the middle dentate gyrus of exercised groups. These results indicate that the adult hippocampus has regional differences in mitotic activity. |
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Authors:
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Katsuya Uchida; Souichiro Nakamura; Tetsuya Kobayashi; Takeo Machida |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neuroreport Volume: 16 ISSN: 0959-4965 ISO Abbreviation: Neuroreport Publication Date: 2005 Dec |
Date Detail:
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Created Date: 2005-11-30 Completed Date: 2006-02-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9100935 Medline TA: Neuroreport Country: England |
Other Details:
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Languages: eng Pagination: 2033-6 Citation Subset: IM |
Affiliation:
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Laboratory of Information Biology, Graduate School of Information Sciences, Tohoku University, Sendai, Japan. uchida@bio.is.tohoku.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Proliferation* Hippocampus / cytology* Male Mice Mice, Inbred C57BL Neurons / cytology* Physical Conditioning, Animal / physiology |
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