Document Detail

Topiramate's effects on cocaine-induced subjective mood, craving and preference for money over drug taking.
MedLine Citation:
PMID:  23039088     Owner:  NLM     Status:  MEDLINE    
Topiramate, presumably through antagonism of excitatory glutaminergic pathways and facilitation of inhibitory gamma-aminobutyric acid neurons in the cortico-mesolimbic system, might reduce cocaine's abuse liability. We tested whether topiramate (100 mg twice daily) would reduce the euphoria, subjective mood, craving and preference for cocaine over money induced by low and high doses (0.325 and 0.65 mg/kg i.v., respectively) of experimentally administered cocaine in 24 male and female, cocaine-dependent, non-treatment-seeking research volunteers in a university in-patient laboratory. We utilized a randomized, double-blind, placebo-controlled, within-subject, Latin-square cross-over design in which three experimental challenge doses of low-dose cocaine, high-dose cocaine and placebo were administered in counterbalanced order after 5 days of topiramate or matching placebo pre-treatments separated by a 1-week washout period (2006-2009). After placebo pre-treatments, cocaine produced dose-related increases in euphoria, stimulant effects, craving for more cocaine and monetary value of cocaine in a behavioral preference test of cocaine versus money choice. Topiramate pre-treatment reduced the cocaine-related craving and monetary value of high-dose cocaine while increasing the monetary value, euphoria and stimulant effects of low-dose cocaine. Validated and standardized human experimental methods evaluating the potential for topiramate to alter cocaine's abuse liability suggest that topiramate may reduce the reinforcing effects and craving induced by higher cocaine doses. Low-dose cocaine might appear to have some enhancement of its stimulant properties in the presence of topiramate's prominent sedative effects.
Bankole A Johnson; John D Roache; Nassima Ait-Daoud; Erik W Gunderson; Heather M Haughey; Xin-Qun Wang; Lei Liu
Related Documents :
8788968 - Enantiospecific inhibition of emesis induced by nicotine in the house musk shrew (suncu...
23689708 - Coadministration of atazanavir-ritonavir and zinc sulfate: impact on hyperbilirubinemia...
25054518 - Toxicological and pharmacokinetic properties of qpi-1007, a chemically modified synthet...
23047118 - A phase 1, randomized, placebo-controlled, three-day, ascending-dose study of gs-9451, ...
8789768 - Effective treatment of acute hyperkalaemia in childhood by short-term infusion of salbu...
424938 - Asthma, high-dose corticosteroids and klebsiella meningitis.
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2012-10-08
Journal Detail:
Title:  Addiction biology     Volume:  18     ISSN:  1369-1600     ISO Abbreviation:  Addict Biol     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-11     Completed Date:  2013-10-17     Revised Date:  2014-05-08    
Medline Journal Info:
Nlm Unique ID:  9604935     Medline TA:  Addict Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  405-16     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors, Addiction Biology © 2012 Society for the Study of Addiction.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Affect / drug effects
Cocaine / pharmacology*
Cocaine-Related Disorders / psychology*
Cross-Over Studies
Dopamine Uptake Inhibitors / pharmacology*
Double-Blind Method
Euphoria / drug effects
Fructose / analogs & derivatives*,  pharmacology
Middle Aged
Neuroprotective Agents / pharmacology*
Patient Preference
Reinforcement (Psychology)
Young Adult
Grant Support
5 R01 DA012191-09/DA/NIDA NIH HHS; R01 DA012191/DA/NIDA NIH HHS
Reg. No./Substance:
0/Dopamine Uptake Inhibitors; 0/Neuroprotective Agents; 0H73WJJ391/topiramate; 30237-26-4/Fructose; I5Y540LHVR/Cocaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Dendritic spine density is altered in a mouse model of Cockayne syndrome.
Next Document:  Spatial gene expression quantification: a tool for analysis of in situ hybridizations in sea anemone...