Document Detail

Topiramate and temporal lobe epilepsy: an open-label study.
MedLine Citation:
PMID:  22576069     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To evaluate the efficacy and tolerability of topiramate (TPM) as monotherapy for patients with temporal lobe epileptic seizures based on an observational study.
METHODS: We evaluated 41 patients (20 female, mean age 54+18 years) with temporal lobe epilepsy (TLE) referred to the Epilepsy Unit, University of Catanzaro, Italy. Patients received TPM as monotherapy directly or after having taken other antiepileptic drugs. Seizure frequency changes and adverse events were recorded. Follow-up was conducted for a period of at least two years after treatment.
RESULTS: Patients received TPM, 50-600 mg/day, de novo (n=29) or initially as add-on therapy before the switch (n=12). In total, 28 of 41 patients achieved seizure freedom, whereas 10 showed a ≥ 50% reduction of seizure frequency. Two patients did not respond well and one patient discontinued TPM due to adverse effects.
CONCLUSIONS: Our results confirm that TPM as either monotherapy or add-on therapy at doses of 50-600 mg/day effectively reduces seizure frequency in TLE. TPM is particular effective and very well tolerated in patients with mild TLE.
Angelo Labate; Antonio Siniscalchi; Laura Mumoli; Umberto Aguglia; Aldo Quattrone; Antonio Gambardella
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Epileptic disorders : international epilepsy journal with videotape     Volume:  14     ISSN:  1294-9361     ISO Abbreviation:  Epileptic Disord     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-25     Completed Date:  2012-10-10     Revised Date:  2013-08-21    
Medline Journal Info:
Nlm Unique ID:  100891853     Medline TA:  Epileptic Disord     Country:  France    
Other Details:
Languages:  eng     Pagination:  163-6     Citation Subset:  IM    
Institute of Neurology, University Magna Græcia, Catanzaro, Italy.
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MeSH Terms
Age of Onset
Anticonvulsants / therapeutic use*
Drug Resistance
Epilepsy, Temporal Lobe / drug therapy*
Fever / complications
Follow-Up Studies
Fructose / analogs & derivatives*,  therapeutic use
Magnetic Resonance Imaging
Middle Aged
Seizures / etiology
Reg. No./Substance:
0/Anticonvulsants; 0H73WJJ391/topiramate; 30237-26-4/Fructose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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