| Topiramate potentiates the antiseizure activity of some anticonvulsants in DBA/2 mice. | |
| | |
MedLine Citation:
|
PMID: 10666508 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Topiramate (1-50 mg/kg, intraperitoneally (i.p.)) was able to antagonize audiogenic seizures in DBA/2 mice in a dose-dependent manner. Topiramate at dose of 2.5 mg/kg i.p., which per se did not significantly affect the occurrence of audiogenic seizures in DBA/2 mice, potentiated the anticonvulsant activity of carbamazepine, diazepam, felbamate, lamotrigine, phenytoin, phenobarbital and valproate against sound-induced seizures in DBA/2 mice. The degree of potentiation induced by topiramate was greatest for diazepam, phenobarbital and valproate, less for lamotrigine and phenytoin and not significant for carbamazepine and felbamate. The increase in anticonvulsant activity was associated with a comparable increase in motor impairment. However, the therapeutic index of the combination of all drugs+topiramate was more favourable than that of antiepileptics+ saline, with the exception of carbamazepine or felbamate+topiramate. Since topiramate did not significantly influence the total and free plasma levels of the anticonvulsant drugs studied, we suggest that pharmacokinetic interactions, in terms of total or free plasma levels, are not probable. However, the possibility that topiramate can modify the clearance from the brain of the anticonvulsant drugs studied cannot be excluded. In addition, topiramate did not significantly affect the hypothermic effects of the anticonvulsants tested. In conclusion, topiramate showed an additive effect when administered in combination with some classical anticonvulsants, most notably diazepam, phenobarbital, lamotrigine, phenytoin and valproate. |
| | |
Authors:
|
G De Sarro; S Gratteri; F Bonacci; S A Musumeci; M Elia; A De Sarro |
Related Documents
:
|
4069378 - Effect of gamma-vinyl gaba on human pattern evoked visual potentials. 1823508 - Critical comment on the determination of plasma level of antiepileptic drugs in the tre... 23289138 - Monoclonal antibody: the corner stone of modern biotherapeutics. 23322138 - Novel strategies for managing dyslipidemia: treatment beyond statins. 22652548 - Design and characterization of a novel amphiphilic chitosan nanocapsule-based thermo-ge... 8746278 - Asthma. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: European journal of pharmacology Volume: 388 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 2000 Jan |
Date Detail:
|
Created Date: 2000-03-16 Completed Date: 2000-03-16 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 163-70 Citation Subset: IM |
Affiliation:
|
Chair of Pharmacology, Department of Experimental and Clinical Medicine, Faculty of Medicine and Surgery, University of Catanzaro, Policlinico Mater Domini, Via T. Campanella, 88100, Catanzaro, Italy. desarro@unicz.it |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acoustic Stimulation Animals Anticonvulsants / blood, pharmacology* Body Temperature / drug effects Dose-Response Relationship, Drug Drug Synergism Female Fructose / analogs & derivatives*, pharmacology Male Mice Mice, Inbred DBA Motor Activity / drug effects Postural Balance / drug effects Seizures / prevention & control* |
| Chemical | |
Reg. No./Substance:
|
0/Anticonvulsants; 30237-26-4/Fructose; 97240-79-4/topiramate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Characterization and modulation of [125I]iberiotoxin-D19Y/Y36F binding in the guinea-pig urinary bla...
Next Document: Effects of zatebradine and propranolol on canine ischemia and reperfusion-induced arrhythmias.