Document Detail

Topiramate: a new agent for patients with alternating hemiplegia of childhood.
MedLine Citation:
PMID:  17177149     Owner:  NLM     Status:  MEDLINE    
Alternating hemiplegia of childhood is a rare syndrome characterized by the onset, before 18 months of age, of frequent attacks of alternating paralysis. Here we report the efficacy of topiramate in four patients with alternating hemiplegia of childhood (AHC) that did not respond to flunarizine, as well as in two newly diagnosed patients. Following treatment with topiramate, the frequency and duration of hemiplegic attacks significantly improved in all patients. Additional symptoms such as seizures, migraine, involuntary movements, autonomic symptoms, and impaired mental development also improved. Topiramate is worth trying when treating patients with AHC as a first trial, or a substitute for flunarizine once the latter agent loses effect.
Wj Jiang; Zf Chi; L Ma; Bf Du; W Shang; Hz Guo; W Wu
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Neuropediatrics     Volume:  37     ISSN:  0174-304X     ISO Abbreviation:  Neuropediatrics     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-12-20     Completed Date:  2007-03-02     Revised Date:  2013-08-21    
Medline Journal Info:
Nlm Unique ID:  8101187     Medline TA:  Neuropediatrics     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  229-33     Citation Subset:  IM    
Department of Neurology, Qilu Hospital of Shandong University, Jinan, China.
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MeSH Terms
Anticonvulsants / therapeutic use
Child, Preschool
Dose-Response Relationship, Drug
Fructose / analogs & derivatives*,  therapeutic use
Hemiplegia / complications,  drug therapy*
Neuroprotective Agents / therapeutic use*
Seizures / drug therapy,  etiology
Time Factors
Treatment Outcome
Reg. No./Substance:
0/Anticonvulsants; 0/Neuroprotective Agents; 0H73WJJ391/topiramate; 30237-26-4/Fructose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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