| Topiramate-induced acute bilateral angle closure and myopia: pathophysiology and treatment controversies. | |
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MedLine Citation:
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PMID: 21058272 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Purpose. To discuss the unusual features of topiramate-induced acute angle closure glaucoma, its pathophysiologic mechanisms, and treatment controversies, and to report the first anterior segment optical coherence tomography (OCT) of this condition. Methods. Literature review and case report with OCT findings. Results. Topiramate-induced angle closure is usually bilateral and associated with acute myopia; the ocular pressure is often not very highly elevated. Ciliochoroidal detachment with ciliary body anterior rotation is typically present and was demonstrated easily in our case with anterior segment OCT. Pilocarpine exacerbates this condition and peripheral iridotomy is not indicated, nor is iridoplasty. Treatment consists of replacing topiramate with appropriate medication, strong cycloplegia, and topical steroids. Conclusions. It is important to recognize this form of acute secondary angle closure in order to treat it properly, avoiding harmful medication and unnecessary surgery. |
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Authors:
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Christopher van Issum; Nikolaos Mavrakanas; James S Schutz; Tarek Shaarawy |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of ophthalmology Volume: 21 ISSN: 1724-6016 ISO Abbreviation: Eur J Ophthalmol Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-12-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9110772 Medline TA: Eur J Ophthalmol Country: Italy |
Other Details:
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Languages: eng Pagination: 404-9 Citation Subset: IM |
Affiliation:
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Glaucoma Sector, Ophthalmology Department, Geneva University Hospitals, Geneva - Switzerland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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