| Topiramate in long-term treatment of epilepsy in the intellectually disabled. | |
| | |
MedLine Citation:
|
PMID: 15713193 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: To study the effectiveness of topiramate (TPM) in refractory epilepsy in patients who have intellectual disability (ID). METHODS: A representative population sample of 57 patients with ID (age range 2-61, mean 32.8) was administered add-on TPM for drug-refractory epilepsy. RESULTS: Seizure freedom for at least for 6 months was attained by 10 (17%), and seizure reduction of > or = 50% by further 26 (46%). Less than 50% decrease in seizure frequency was found in 16 (29%). TPM was more efficacious in localisation-related than in generalised epilepsies (81% vs. 50%, P=0.019). An at least 50% decrease in seizure frequency was achieved by patients with temporal lobe epilepsy in 100%, continuous spike-waves during sleep syndrome in 75%, Lennox-Gastaut syndrome in 52%, and those with infantile spasms in 25% of cases. As great decrease in seizure frequency was found in most patients with cortical dysplasia (83%), acquired encephalopathy with mesial temporal sclerosis (MTS) (75%), and genetic disease associated with MTS (66%). Adverse effects occurred in 10% including two (3%) with seizure aggravation and three (5%) necessitating discontinuation. CONCLUSION: TPM is an effective antiepileptic drug which is of value in treating people with seizures that are resistant to other antiepileptic medication. As a broad-spectrum drug it may substitute for polypharmacy and, at the same time decrease adverse effects and costs of therapy. |
| | |
Authors:
|
M Arvio; M Sillanpää |
Related Documents
:
|
6781233 - Anterior callosotomy in epileptics with multiform seizures and bilateral synchronous sp... 17362273 - Hippocampal volumes and diffusion-weighted image findings in children with prolonged fe... 8158733 - Otosyphilis: diagnostic and therapeutic update. |
Publication Detail:
|
Type: Clinical Trial; Journal Article |
Journal Detail:
|
Title: Journal of intellectual disability research : JIDR Volume: 49 ISSN: 0964-2633 ISO Abbreviation: J Intellect Disabil Res Publication Date: 2005 Mar |
Date Detail:
|
Created Date: 2005-02-16 Completed Date: 2005-06-09 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9206090 Medline TA: J Intellect Disabil Res Country: England |
Other Details:
|
Languages: eng Pagination: 183-9 Citation Subset: IM |
Affiliation:
|
Pääjärvi Centre, Lammi, Turku University, Turku, Finland. arvio@mail.htk.fi |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Anticonvulsants / therapeutic use* Brain / pathology, physiopathology Electroencephalography Epilepsy / complications*, diagnosis, drug therapy*, epidemiology Female Follow-Up Studies Fructose / analogs & derivatives*, therapeutic use* Humans Magnetic Resonance Imaging Male Mental Retardation / complications* Middle Aged Periodicity Retrospective Studies |
| Chemical | |
Reg. No./Substance:
|
0/Anticonvulsants; 30237-26-4/Fructose; 97240-79-4/topiramate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Social outcomes in adulthood of children with intellectual impairment: evidence from a birth cohort.
Next Document: Enhancing primary health care services for adults with intellectual disabilities.