Document Detail

Topiramate use and the risk of glaucoma development: a population-based follow-up study.
MedLine Citation:
PMID:  23022160     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To investigate the risk of glaucoma development after being prescribed topiramate.
DESIGN: A retrospective, population-based cohort study using an administrative database.
METHODS: The study group comprised 1956 patients who received their first prescription of topiramate between 2001 and 2007. The comparison cohort consisted of 15 648 randomly matched patients who never took topiramate. Each sampled patient was traced for a 1-year period from his or her index date to identify patients who subsequently received a diagnosis of glaucoma.
RESULTS: Glaucoma was diagnosed in 0.36%, 0.05%, and 0.66% of the study cohort during the first month, second to third month, and fourth to twelfth month following the index date, respectively. For the comparison cohort, glaucoma was diagnosed in 0.04%, 0.11%, and 0.46% of subjects during the first month, second to third month, and fourth to twelfth month following the index date, respectively. After adjusting for potential confounding factors, patients prescribed topiramate were found to have a 7.41-fold (95% confidence interval [CI] = 2.45-22.46) greater risk of subsequently being diagnosed with glaucoma than the comparison cohort during the first month after the index date. However, this association became statistically nonsignificant during the second-to-third-month and fourth-to-twelfth-month periods following the index date between the 2 cohorts (adjusted hazard ratio, 0.56, 95% CI = 0.07-4.29; and 1.35, 95% CI = 0.74-2.47, respectively).
CONCLUSIONS: Topiramate use in Taiwan was associated with a significantly increased risk of being diagnosed with glaucoma within the first month after receiving a prescription for the drug.
Jau-Der Ho; Joseph J Keller; Ching-Yao Tsai; Shiow-Wen Liou; Chih-Ju Chang; Herng-Ching Lin
Publication Detail:
Type:  Journal Article     Date:  2012-09-27
Journal Detail:
Title:  American journal of ophthalmology     Volume:  155     ISSN:  1879-1891     ISO Abbreviation:  Am. J. Ophthalmol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-14     Completed Date:  2013-03-14     Revised Date:  2013-08-21    
Medline Journal Info:
Nlm Unique ID:  0370500     Medline TA:  Am J Ophthalmol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  336-341.e1     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2013 Elsevier Inc. All rights reserved.
Department of Ophthalmology, Taipei Medical University Hospital, Taipei, Taiwan.
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MeSH Terms
Anticonvulsants / adverse effects*
Databases, Factual
Follow-Up Studies
Fructose / adverse effects,  analogs & derivatives*
Glaucoma / chemically induced*
Middle Aged
National Health Programs / statistics & numerical data
Retrospective Studies
Risk Factors
Taiwan / epidemiology
Young Adult
Reg. No./Substance:
0/Anticonvulsants; 0H73WJJ391/topiramate; 30237-26-4/Fructose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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