Document Detail

Topical vitamin D3 (tacalcitol) for steroid-resistant prurigo.
MedLine Citation:
PMID:  8881666     Owner:  NLM     Status:  MEDLINE    
A topical vitamin D3 ointment (tacalcitol) was prescribed for patients with long-lasting pruriginous lesions (four with prurigo nodularis and seven with subacute prurigo, four of whom had atopic dermatitis). Seven of 11 cases had not responded to a topical steroid ointment and even to occlusive application of the ointment. Nine of 11 cases showed a significant clinical response to this new regimen within 4 weeks. Epidermal Fc epsilon R1(+) dendritic cells were increased in number in prurigo nodularis and reduced to normal level after the therapy. Topical vitamin D3 ointment might be an alternative therapy for steroid-resistant prurigo.
I Katayama; Y Miyazaki; K Nishioka
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The British journal of dermatology     Volume:  135     ISSN:  0007-0963     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  1996 Aug 
Date Detail:
Created Date:  1996-12-16     Completed Date:  1996-12-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  237-40     Citation Subset:  IM    
Department of Dermatology, Tokyo Medical and Dental University School of Medicine, Japan.
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MeSH Terms
Administration, Topical
Cell Adhesion Molecules / analysis
Cholecalciferol / administration & dosage,  therapeutic use*
Drug Resistance
Middle Aged
Prurigo / drug therapy*
Skin / metabolism
Reg. No./Substance:
0/Cell Adhesion Molecules; 67-97-0/Cholecalciferol

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