| Topical use of glyceryl-trinitrate in the treatment of anal fissure | |
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MedLine Citation:
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PMID: 19536057 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: Anal fissure is associated with hypertonia of the internal anal sphincter and pain. Lateral internal sphincterotomy, the most common treatment, may cause permanent injury to the anal sphincter, which can lead to fecal incontinence. The aim of this study was to evaluate the effectiveness of topical glyceryl trinitrate (GTN) ointment in the treatment of anal fissure. METHODS: Twenty-four patients (12 males and 12 females, mean age 45 years) with anal fissure received 0.4% GTN gel twice a day for a minimum of six weeks. All patients were followed at regular intervals of 2, 6, 12 weeks to assess symptom outcome, rate of healing, adverse effects and recurrence rate. RESULTS: The symptomatology was significantly improved already from the second week of treatment in 18 patients (75%). Thirteen patients (54%) healed after six weeks, and 14 (58%) after 12 weeks, while three patients (13%) partially healed but asymptomatic. Fecal incontinence was absent. In two patients (8%) treatment was interrupted because of severe headaches. At the end of the treatment, only three patients (13%) underwent lateral sphincterotomy. CONCLUSIONS: Topical application of GTN ointment heals anal fissures and represents an alternative to the traditional first-line treatment of surgical sphincterotomy. |
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Authors:
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F Corno; A Marano; S Volpatto; P Mistrangelo |
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Publication Detail:
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Type: Clinical Trial; English Abstract; Journal Article |
Journal Detail:
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Title: Minerva chirurgica Volume: 64 ISSN: 0026-4733 ISO Abbreviation: Minerva Chir Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-06-18 Completed Date: 2009-12-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0400726 Medline TA: Minerva Chir Country: Italy |
Other Details:
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Languages: ita Pagination: 307-11 Citation Subset: IM |
Affiliation:
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Chirurgia Generale 1, Universit?? degli Studi di Torino, Azienda Ospedaliero-Universitaria,Torino, Italia. |
Vernacular Title:
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Uso topico di gliceril-trinitrato nel trattamento della ragade anale. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Cutaneous Anal Canal / surgery Female Fissure in Ano / drug therapy*, surgery Humans Male Medication Adherence Middle Aged Nitroglycerin / administration & dosage, therapeutic use* Ointments / therapeutic use Retrospective Studies Time Factors Treatment Outcome Vasodilator Agents / administration & dosage, therapeutic use* Wound Healing |
| Chemical | |
Reg. No./Substance:
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0/Ointments; 0/Vasodilator Agents; 55-63-0/Nitroglycerin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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