| Topical treatment with a new matrix therapy agent (RGTA) for the treatment of corneal neurotrophic ulcers. | |
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MedLine Citation:
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PMID: 23150626 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE: Neurotrophic keratopathy is a degenerative disease of the corneal epithelium resulting from impaired corneal innervation, possibly leading to perforation. We aimed to assess the efficacy and tolerance of a new matrix therapy agent (RGTA, CACICOL20), mimicking heparan-sulfates, for the management of neurotrophic keratopathy. Methods: We carried out an uncontrolled, prospective, single-centre clinical study on eleven patients (eleven eyes) with severe corneal neurotrophic ulcers, despite the use of preservative-free artificial tears for 15 days. They were treated with RGTA eye drops, instilled at a dose of one drop in the morning, on alternate days. Evolution and follow-up during treatment were evaluated by slit-lamp examination, photography, fluorescein-dye testing, tests of corneal sensitivity and best corrected visual acuity. The main outcome measures for each patient were healing of the corneal surface and best corrected visual acuity before and after RGTA therapy. Results: Eight patients displayed complete corneal healing, after a mean period of 8.7 weeks (range; 1 to 22 weeks). Mean ulcer area decreased significantly, from 11.12% to 6.37% (P=0.048) in the first week, and to 1.56% (P=0.005) at one month. Treatment failure was observed in three cases, requiring amniotic membrane transplantation in two patients and penetrating keratoplasty in one patient. At the end of the study, none of the patients displayed significant improvement in visual acuity. There were no systemic or local side effects of treatment. Conclusions: RGTA seems to be a potentially useful, alternative, non-invasive therapeutic approach in neurotrophic keratopathy management. However, randomized studies are necessary. |
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Authors:
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Abdelouahab Aifa; Julie Gueudry; Alexandre Portmann; Agnes Delcampe; Marc Muraine |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-11-13 |
Journal Detail:
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Title: Investigative ophthalmology & visual science Volume: - ISSN: 1552-5783 ISO Abbreviation: Invest. Ophthalmol. Vis. Sci. Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-11-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7703701 Medline TA: Invest Ophthalmol Vis Sci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Ophthalmology Department, Rouen University Hospital-Charles Nicolle, 1 rue de Germont, Rouen, 76031, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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