Document Detail


Topical treatment of ulcerative colitis.
MedLine Citation:
PMID:  1967326     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It is clear that the therapeutic options available for the treatment of ulcerative proctosigmoiditis have increased over the last few years and in the future additional therapies will be available. Therapy will have to be individualized. Studies to date have generally failed to confirm the superiority of one form of treatment over another, although there is some evidence that high-dose 5-ASA enemas are superior to hydrocortisone enemas. Patients who fail to respond to one form of therapy may respond to another therapeutic modality. Continued evaluation of topical therapies provides not only an opportunity to improve the treatment prospects for patients but also allows for examination of potential mechanisms of action of therapeutically active compounds. Future research directions should also include assessment of combination therapy, the more widespread use of suppositories, and strategies to encourage patient compliance. Larger multicenter trials are needed to assess the effectiveness of some of the newer compounds. The role of topical therapy for patients with Crohn's disease confined to the left colon requires evaluation.
Authors:
L R Sutherland
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The Medical clinics of North America     Volume:  74     ISSN:  0025-7125     ISO Abbreviation:  Med. Clin. North Am.     Publication Date:  1990 Jan 
Date Detail:
Created Date:  1990-02-20     Completed Date:  1990-02-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  2985236R     Medline TA:  Med Clin North Am     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  119-31     Citation Subset:  AIM; IM    
Affiliation:
Division of Gastroenterology, University of Calgary, Alberta, Canada.
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MeSH Terms
Descriptor/Qualifier:
Absorption
Administration, Topical
Adrenal Cortex Hormones / administration & dosage,  therapeutic use
Aminosalicylic Acids / administration & dosage,  pharmacokinetics,  therapeutic use
Colitis, Ulcerative / drug therapy*
Cromolyn Sodium / therapeutic use
Dose-Response Relationship, Drug
Enema
Evaluation Studies as Topic
Humans
Mesalamine
Sucralfate / therapeutic use
Sulfasalazine / administration & dosage,  therapeutic use
Suppositories
Chemical
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Aminosalicylic Acids; 0/Suppositories; 15826-37-6/Cromolyn Sodium; 54182-58-0/Sucralfate; 599-79-1/Sulfasalazine; 89-57-6/Mesalamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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