Document Detail

Topical treatment of recurrent genital herpes simplex virus infections with trisodium phosphonoformate (foscarnet): double blind, placebo controlled, multicentre study.
MedLine Citation:
PMID:  2942457     Owner:  NLM     Status:  MEDLINE    
A double blind, placebo controlled trial was performed in nine sexually transmitted diseases (STD) clinics in the United Kingdom and the Netherlands to investigate the efficacy of trisodium phosphonoformate (foscarnet) cream in treating recurrent genital herpes simplex virus (HSV) infection. The study group comprised 145 male and 85 female patients. Men received 0.3% foscarnet cream and women 1% foscarnet cream for five days. The difference in time to healing between patients receiving foscarnet or placebo was not significant. Fewer patients treated with foscarnet had positive viral cultures after treatment, but the difference was not significant. The development of new lesions, however, was significantly less common in patients given foscarnet. Though topical foscarnet is a safe drug, no appreciable efficacy in treating recurrent genital HSV infection could be shown.
S E Barton; P E Munday; G R Kinghorn; W I van der Meijden; E Stolz; A Notowicz; S Rashid; J L Schuller; A J Essex-Cater; M H Kuijpers
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Genitourinary medicine     Volume:  62     ISSN:  0266-4348     ISO Abbreviation:  Genitourin Med     Publication Date:  1986 Aug 
Date Detail:
Created Date:  1986-09-25     Completed Date:  1986-09-25     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  8503853     Medline TA:  Genitourin Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  247-50     Citation Subset:  IM    
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MeSH Terms
Administration, Topical
Clinical Trials as Topic
Double-Blind Method
Herpes Genitalis / drug therapy*
Organophosphorus Compounds / therapeutic use*
Phosphonoacetic Acid / administration & dosage,  analogs & derivatives,  therapeutic use*
Time Factors
Reg. No./Substance:
0/Organophosphorus Compounds; 4408-78-0/Phosphonoacetic Acid; 4428-95-9/Foscarnet

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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