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Topical tazarotene cream (0.1%) in the treatment of facial acne: an open clinical trial.
MedLine Citation:
PMID:  21473199     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
BACKGROUND: Tazarotene is a new 3rd generation topical acetylenic retinoid. It normalizes keratinocyte differentiation, reduces keratinocyte proliferation and decreases expression of inflammatory markers. Tazarotene was approved by U.S.F.D.A. in 1997 for acne vulgaris.
OBJECTIVES: To evaluate the efficacy and safety of topical tazarotene 0.1% cream in the treatment of facial acne.
MATERIALS AND METHODS: 67 patients with facial acne in the age range of 13-30 years were enrolled in the study. Purposive sampling was done. Patients were treated with topical Tazarotene cream (0.1%) and were instructed to apply the medication as a thin film over the affected area in the evening once daily for 12 weeks. Follow-up was done at 2nd, 4th week, 8th week and at 12th week.
RESULTS: Of the 67 patients, 53% got remission, 9% had good response, 34% had poor response and there was no response in 4% of the patients by 12 weeks of treatment. Among the patients, 9 (13.43%) developed mild side effects.
CONCLUSION: Topical tazarotene cream (0.1%) is a effective and safe treatment option for acne vulgaris affecting face. It is mostly effective in grade-1 and grade-2 acne.
Authors:
A S M Zakaria; H K Paul; M A Rahman; M T Islam; A M Choudhury
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bangladesh Medical Research Council bulletin     Volume:  36     ISSN:  0377-9238     ISO Abbreviation:  Bangladesh Med Res Counc Bull     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2011-04-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7607686     Medline TA:  Bangladesh Med Res Counc Bull     Country:  Bangladesh    
Other Details:
Languages:  eng     Pagination:  43-6     Citation Subset:  IM    
Affiliation:
Department of Dermatology & Venereology, Bangabandhu Sheikh Mujib Medical University, Dhaka.
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