Document Detail


Topical tacrolimus does not negatively impact acute skin wound healing.
MedLine Citation:
PMID:  23614749     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Despite the increasing use of topical tacrolimus, there is little information about its effect on skin wound healing. To determine effects on acute cutaneous wound healing, two full-thickness skin wounds were imparted on the backs of 45 hairless mice, which were then divided into vehicle-, topical tacrolimus- and topical steroid-treated group. Each drug was topically applied once daily. The wound area was assessed by using dermoscopic images every two days after wounding. At 3, 7 and 11 days after wounding, 10 wounds in each group were collected for semi-quantitative analysis of histological features including re-epithelialization, polymorphonuclear leucocytes, fibroblasts and collagen. We also checked the mRNA expression levels of EGF, TGF-β, TNF-α and IL-1α. While topical application of clobetasol propionate was found to delay re-epithelialization and infiltration of polymorphonuclear leucocyte, topical treatment with tacrolimus showed patterns similar to that of the vehicle. In the tacrolimus-treated group, mRNA expression levels of IL-1α and TGF-β were slightly decreased, while the others were similar with the vehicle-treated group. Unlike steroid, topical tacrolimus, therefore, did not disturb the wound healing process in a murine skin wound model.
Authors:
Sun Namkoong; Jimin Chung; Jiyeon Yoo; Minyoung Jung; Jiwon Gye; Ji Seok Kim; Jee Young Kim; Sung Ku Ahn; Byung Cheol Park; Myung Hwa Kim; Seung Phil Hong
Related Documents :
8803769 - A fluorimetric enzyme assay for the diagnosis of sanfilippo disease type a (mps iiia).
17407189 - Prolonged expression of a lysosomal enzyme in mouse liver after sleeping beauty transpo...
24732399 - Basis for enhanced barrier function of pigmented skin.
114339 - A fluorometric assay using 4-methylumbelliferyl alpha-l-iduronide for the estimation of...
11099229 - Cyclo(dehydroala-l-leu), an alpha-glucosidase inhibitor from penicillium sp. f70614.
1900419 - Alpha-l-iduronidase in normal and mucopolysaccharidosis-type-i human skin fibroblasts.
17884289 - Cat odor exposure induces distinct changes in the exploratory behavior and wfs1 gene ex...
9457469 - Immunophenotyping of lymphocytes in the lung interstitium and expression of osteopontin...
24463449 - Nrf2-mediated notch pathway activation enhances hematopoietic reconstitution following ...
Publication Detail:
Type:  Letter    
Journal Detail:
Title:  Experimental dermatology     Volume:  22     ISSN:  1600-0625     ISO Abbreviation:  Exp. Dermatol.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9301549     Medline TA:  Exp Dermatol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  369-71     Citation Subset:  IM    
Copyright Information:
© 2013 John Wiley & Sons A/S.
Affiliation:
Department of Dermatology, College of Medicine, Dankook University, Cheonan, Korea.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Dynamics of intracellular calcium in cultured human keratinocytes after localized cell damage.
Next Document:  Curcumin inhibits UVB-induced matrix metalloproteinase-1/3 expression by suppressing the MAPK-p38/JN...