Document Detail


Topical tacrolimus (FK506) and mometasone furoate in treatment of dyshidrotic palmar eczema: a randomized, observer-blinded trial.
MedLine Citation:
PMID:  11756949     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Dyshidrotic palmoplantar eczema is a frequent disease often running a chronic relapsing course. Topical glucocorticosteroids form the mainstay of therapy, and alternatives are urgently warranted. OBJECTIVE: This study was performed to compare the efficacy of tacrolimus (FK506) 0.1% ointment and mometasone furoate 0.1% ointment in the treatment of dyshidrotic palmoplantar eczema. METHODS: Sixteen patients were included in the study after a randomized, observer-blind, intrapersonal comparison protocol. After a 2-week washout period, the active treatment phase amounted to 4 weeks with twice-daily topical application of test substances and additional use of emollients at will. Thereafter, patients were monitored at weekly intervals up to 8 weeks. RESULTS: The dyshidrotic area and severity index showed a more than 50% reduction of baseline values after 2 weeks of active treatment both for FK506 (P =.003) and mometasone furoate (P =.022) in palmar areas. After active treatment, a nonsignificant increase in the dyshidrotic area and severity index was seen with FK506 treated areas. Fourteen of 16 patients had recurring symptoms requiring further therapy within 3 weeks after the active treatment phase. CONCLUSION: Treatment with FK506 offers the possibility for rotational therapy with mometasone furoate in long-standing cases of chronic dyshidrotic palmar eczema.
Authors:
Christina Schnopp; Roland Remling; Matthias Möhrenschlager; Lorenz Weigl; Johannes Ring; Dietrich Abeck
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of the American Academy of Dermatology     Volume:  46     ISSN:  0190-9622     ISO Abbreviation:  J. Am. Acad. Dermatol.     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2001-12-28     Completed Date:  2002-02-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7907132     Medline TA:  J Am Acad Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  73-7     Citation Subset:  IM    
Affiliation:
Department of Dermatology and Allergy Biederstein, Technical University Munich, Germany. nina.schnopp@lrz.tu-muenchen.de
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MeSH Terms
Descriptor/Qualifier:
Administration, Cutaneous
Adult
Anti-Bacterial Agents / administration & dosage,  therapeutic use*
Anti-Inflammatory Agents / administration & dosage,  therapeutic use*
Eczema, Dyshidrotic / drug therapy*,  pathology
Female
Foot Dermatoses / drug therapy,  pathology
Glucocorticoids
Hand Dermatoses / drug therapy,  pathology
Humans
Immunosuppressive Agents / administration & dosage,  therapeutic use*
Male
Middle Aged
Pregnadienediols / administration & dosage,  therapeutic use*
Severity of Illness Index
Single-Blind Method
Tacrolimus / administration & dosage,  therapeutic use*
Treatment Outcome
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Anti-Inflammatory Agents; 0/Glucocorticoids; 0/Immunosuppressive Agents; 0/Pregnadienediols; 109581-93-3/Tacrolimus; 83919-23-7/mometasone furoate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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