Document Detail

Topical sucralfate in the management of peristomal skin disease: an open study.
MedLine Citation:
PMID:  11167966     Owner:  NLM     Status:  MEDLINE    
Dermatoses affecting the skin around stoma sites are common and difficult to treat. We have investigated the effectiveness of topical sucralfate in the management of peristomal dermatoses in adults using an open study design. Apart from forming a physical barrier to further irritation, sucralfate binds to basic fibroblast growth factor preventing its degradation and thereby promotes healing. In eight out of nine patients with faecal or urine erosions, daily, topical sucralfate treatment was associated with healing within 4 weeks. There was limited or no response to treatment in a further nine patients with traumatic ulcers, excoriated dermatitis or pyoderma gangrenosum. Topical sucralfate represents a safe, inexpensive and effective therapeutic intervention, particularly for those patients with high output or short stomas where repeated stoma leakage may be unavoidable.
C C Lyon; M Stapleton; A J Smith; C E Griffiths; M H Beck
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental dermatology     Volume:  25     ISSN:  0307-6938     ISO Abbreviation:  Clin. Exp. Dermatol.     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2001-02-22     Completed Date:  2001-04-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7606847     Medline TA:  Clin Exp Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  584-8     Citation Subset:  IM    
Dermatology Centre, University of Manchester, and the Pharmacy and the Department of Stoma-Care, Hope Hospital, Salford, UK.
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MeSH Terms
Administration, Topical
Aged, 80 and over
Anti-Ulcer Agents / administration & dosage*
Middle Aged
Skin Diseases / drug therapy*
Sucralfate / administration & dosage*
Surgical Stomas / adverse effects*
Treatment Outcome
Reg. No./Substance:
0/Anti-Ulcer Agents; 54182-58-0/Sucralfate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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