| Topical proparacaine and episcleral venous pressure in the rabbit. | |
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MedLine Citation:
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PMID: 19151377 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To determine the effect of proparacaine-induced topical anesthesia on episcleral venous pressure (EVP). METHODS: In anesthetized rabbits (n = 11), EVP was measured with a servonull micropressure system, with glass pipettes with 2- to 3-microm tips used to cannulate episcleral veins. Additional measurements included arterial, intraocular, and orbital venous pressures obtained by direct cannulation, to assess the ocular pressure gradients, and carotid blood flow and heart rate, to verify preparation stability. The protocol entailed 5 to 10 minutes of stable baseline recording followed by topical application of proparacaine (0.5%, 10 microL) with continued measurements for another 5 to 15 minutes. RESULTS: Baseline EVP without topical anesthesia was 12.3 +/- 1.1 mm Hg. EVP decreased significantly to 8.7 +/- 0.9 mm Hg within minutes after application of proparacaine. A small decrease also occurred in intraocular pressure. All other measured variables were unchanged. CONCLUSIONS: These results suggest that the episcleral circulation is under tonic neural control and that either an upstream resistance site is under tonic vasodilatory control or a downstream site is under vasoconstrictor control. |
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Authors:
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David O Zamora; Jeffrey W Kiel |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2009-01-17 |
Journal Detail:
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Title: Investigative ophthalmology & visual science Volume: 50 ISSN: 1552-5783 ISO Abbreviation: Invest. Ophthalmol. Vis. Sci. Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-05-27 Completed Date: 2009-06-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7703701 Medline TA: Invest Ophthalmol Vis Sci Country: United States |
Other Details:
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Languages: eng Pagination: 2949-52 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, University of Texas Health Science Center, San Antonio, Texas 78229, USA. zamorado@uthscsa.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Anesthesia, Local / methods* Anesthetics, Local / administration & dosage* Animals Female Heart Rate / physiology Intraocular Pressure / physiology Male Propoxycaine / administration & dosage* Rabbits Regional Blood Flow Sclera / blood supply* Transducers, Pressure Venous Pressure / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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EY09702/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Local; 499-67-2/proxymetacaine; 86-43-1/Propoxycaine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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