Document Detail


Topical proparacaine and episcleral venous pressure in the rabbit.
MedLine Citation:
PMID:  19151377     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To determine the effect of proparacaine-induced topical anesthesia on episcleral venous pressure (EVP).
METHODS: In anesthetized rabbits (n = 11), EVP was measured with a servonull micropressure system, with glass pipettes with 2- to 3-microm tips used to cannulate episcleral veins. Additional measurements included arterial, intraocular, and orbital venous pressures obtained by direct cannulation, to assess the ocular pressure gradients, and carotid blood flow and heart rate, to verify preparation stability. The protocol entailed 5 to 10 minutes of stable baseline recording followed by topical application of proparacaine (0.5%, 10 microL) with continued measurements for another 5 to 15 minutes.
RESULTS: Baseline EVP without topical anesthesia was 12.3 +/- 1.1 mm Hg. EVP decreased significantly to 8.7 +/- 0.9 mm Hg within minutes after application of proparacaine. A small decrease also occurred in intraocular pressure. All other measured variables were unchanged.
CONCLUSIONS: These results suggest that the episcleral circulation is under tonic neural control and that either an upstream resistance site is under tonic vasodilatory control or a downstream site is under vasoconstrictor control.
Authors:
David O Zamora; Jeffrey W Kiel
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2009-01-17
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  50     ISSN:  1552-5783     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-27     Completed Date:  2009-06-11     Revised Date:  2013-01-31    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2949-52     Citation Subset:  IM    
Affiliation:
Department of Ophthalmology, University of Texas Health Science Center, San Antonio, Texas 78229, USA. zamorado@uthscsa.edu
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MeSH Terms
Descriptor/Qualifier:
Administration, Topical
Anesthesia, Local / methods*
Anesthetics, Local / administration & dosage*
Animals
Female
Heart Rate / physiology
Intraocular Pressure / physiology
Male
Propoxycaine / administration & dosage*
Rabbits
Regional Blood Flow
Sclera / blood supply*
Transducers, Pressure
Venous Pressure / physiology*
Grant Support
ID/Acronym/Agency:
EY09702/EY/NEI NIH HHS; R01 EY009702/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/Anesthetics, Local; 86-43-1/Propoxycaine; B4OB0JHI1X/proxymetacaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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