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Topical photodynamic therapy significantly reduces epidermal Langerhans cells during clinical treatment of basal cell carcinoma.
MedLine Citation:
PMID:  22242712     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background:  Topical photodynamic therapy (PDT) is a widely applied treatment for basal cell carcinoma (BCC). PDT-induced immunosuppression leading to ineffective anti-tumour immune responses may be a factor in treatment failure. Objective:  To examine the impact of topical PDT on leucocyte trafficking following clinical treatment of BCC. Methods:  Superficial BCC in eight white Caucasian patients were treated with methyl aminolaevulinate (MAL)-PDT. Biopsies for immunohistochemical assessment were taken from BCC pre-PDT, 1h and 24h post-PDT and from untreated healthy skin. Results:  Treatment of BCC with MAL-PDT produced a rapid neutrophil infiltration, commencing by 1h and significantly increased at 24h post-PDT (p<0.05 compared to baseline). An associated increase in the number of blood vessels expressing E-selectin was observed at 1h and 24h post-PDT (both p<0.05 compared to baseline). In contrast, the number of epidermal Langerhans cells fell sharply by 1h post-PDT, and remained significantly reduced at 24h post-PDT (both p<0.05 compared to baseline). Conclusions:  Reduction of Langerhans cells during clinical treatment of BCC might potentially impact negatively on anti-tumour responses through reduced activation of tumour-specific effector cells. Investigation of modified PDT protocols with the aim to minimise immunosuppressive effects whilst maintaining anti-tumour efficacy is warranted.
Authors:
G Evangelou; M D Farrar; L Cotterell; S Andrew; A D Tosca; R E B Watson; L E Rhodes
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-13
Journal Detail:
Title:  The British journal of dermatology     Volume:  -     ISSN:  1365-2133     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 British Association of Dermatologists.
Affiliation:
Dermatological Sciences, Inflammation Sciences Research Group, School of Translational Medicine, University of Manchester, Manchester Academic Health Science Centre, Salford Royal NHS Foundation Hospital, Manchester, UK Department of Cellular Pathology, Salford Royal NHS Foundation Hospital, Manchester, UK University Hospital of Crete, Heraklion, Crete, Greece.
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