Document Detail


Topical photodynamic therapy of murine non-melanoma skin carcinomas with aluminum phthalocyanine chloride and a diode laser: pharmacokinetics, tumor response and cosmetic outcomes.
MedLine Citation:
PMID:  18353089     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND/PURPOSE: Topical photodynamic therapy (PDT) is potentially useful for the treatment of non-melanoma skin cancer and other skin diseases. We investigated the therapeutic effects of PDT using topical application of aluminum phthalocyanine chloride (AlClPc) and a diode laser emitting at 670 nm in murine non-melanoma skin carcinomas. METHODS: AlClPc solution (0.7% w/v) was applied to tumors in mice for 1-6 h. The penetration depth and the optimum drug-light interval were assessed using pharmacokinetic studies. Then, PDT was performed on a murine model of non-melanoma skin cancer using seven different combinations of therapeutic parameters (fluence rate and energy dose). RESULTS: Pharmacokinetic studies revealed that AlClPc was absorbed 40 times more and penetrated 19 times deeper in tumors than normal skin. PDT using AlClPc (0.7% w/v) and a diode laser (75 mW/cm(2), 150 J/cm(2)) resulted in complete tumor remission in 60% of the mice, excellent cosmetic outcomes and growth retardation of tumors with partial remission. CONCLUSIONS: The results indicate that AlClPc-PDT is an effective treatment for non-melanoma skin carcinomas in experimental mouse models.
Authors:
Maria Kyriazi; Eleni Alexandratou; Dido Yova; Michail Rallis; Tilmann Trebst
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Photodermatology, photoimmunology & photomedicine     Volume:  24     ISSN:  1600-0781     ISO Abbreviation:  Photodermatol Photoimmunol Photomed     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-20     Completed Date:  2008-04-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9013641     Medline TA:  Photodermatol Photoimmunol Photomed     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  87-94     Citation Subset:  IM    
Affiliation:
School of Electrical and Computer Engineering, National Technical University of Athens, Athens, Greece. chmaria@central.ntua.gr
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MeSH Terms
Descriptor/Qualifier:
Administration, Cutaneous
Animals
Carcinoma, Basal Cell / drug therapy*,  metabolism,  pathology
Female
Indoles / administration & dosage*,  pharmacokinetics
Male
Mice
Mice, Inbred Strains
Neoplasm Recurrence, Local / drug therapy*,  pathology
Neoplasm Transplantation
Organometallic Compounds / administration & dosage*,  pharmacokinetics
Photochemotherapy*
Photosensitizing Agents / administration & dosage*,  pharmacokinetics
Skin Neoplasms / drug therapy*,  metabolism,  pathology
Chemical
Reg. No./Substance:
0/Indoles; 0/Organometallic Compounds; 0/Photosensitizing Agents; 14154-42-8/chloroaluminum phthalocyanine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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