Document Detail


Topical phenylephrine increases anal canal resting pressure in patients with faecal incontinence.
MedLine Citation:
PMID:  11171825     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: The internal anal sphincter receives a stimulatory alpha(1) adrenergic innervation. Use of an adrenergic agonist may therefore have a role in treating patients with faecal incontinence. METHODS: Ten patients (seven females, median age 66 years) with passive faecal incontinence related to weak internal anal sphincter were studied. All patients had intact anal sphincters as assessed by endoanal ultrasound. Phenylephrine gel was applied in a double blind manner in concentrations of 0%, 10%, 20%, 30%, and 40% (Slaco Pharma (UK) Ltd, Watford, UK) on separate days. Maximum resting anal pressure (MRP), anodermal blood flow, blood pressure, and pulse rate were measured before, and one and two hours after application. RESULTS: All concentrations of phenylephrine gel increased median MRP (43, 48, 54, 65, and 70 cm H(2)O, for placebo, 10% (p=0.122), 20% (p=0.170), 30% (p=0.002), and 40% (p=0.004), respectively at one hour; comparisons with placebo). This was sustained at two hours. There was a clear dose-response relationship at one hour. Higher concentrations raised median MRP to within the normal range (> 60 cm H(2)O). At two hours, all concentrations greater than 20% increased the pressure to a similar degree, suggesting that the exact concentration may be important for the initial effect but given a certain threshold is less important after a period of time. Toxicity was rare. Two patients experienced transient perianal burning which settled within a few minutes. There was no significant effect on anodermal blood flow, blood pressure, or pulse rate. CONCLUSION: This study has demonstrated the feasibility of using topical phenylephrine to raise resting anal tone in patients with faecal incontinence. Randomised controlled trials are required to assess the efficacy of this agent.
Authors:
M J Cheetham; M A Kamm; R K Phillips
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Gut     Volume:  48     ISSN:  0017-5749     ISO Abbreviation:  Gut     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-02-22     Completed Date:  2001-04-12     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  England    
Other Details:
Languages:  eng     Pagination:  356-9     Citation Subset:  AIM; IM    
Affiliation:
St Mark's Hospital, Watford Road, Harrow, Middlesex HA1 3UJ, UK.
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MeSH Terms
Descriptor/Qualifier:
Administration, Topical
Adrenergic alpha-Agonists / administration & dosage*
Aged
Anal Canal / blood supply
Anus Diseases / drug therapy*
Blood Pressure / drug effects
Dose-Response Relationship, Drug
Double-Blind Method
Fecal Incontinence / drug therapy*
Female
Gels
Heart Rate / drug effects
Humans
Male
Manometry
Phenylephrine / administration & dosage*
Regional Blood Flow
Chemical
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 0/Gels; 59-42-7/Phenylephrine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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