| Topical oxygen as an adjunct to wound healing: a clinical case series. | |
| | |
MedLine Citation:
|
PMID: 14567939 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: Disrupted vasculature and high energy-demand to support processing and regeneration of wounded tissue are typical characteristics of a wound site. Oxygen delivery is a critical element for the healing of wounds. Clinical experience with adjunctive hyperbaric oxygen therapy in the treatment of chronic wounds have shown that wound hyperoxia increases wound granulation tissue formation and accelerates wound contraction and secondary closure. Nevertheless, the physiologic basis for this modality remains largely unknown. Also, systemic hyperbaric oxygen therapy is associated with risks related to oxygen toxicity. Topical oxygen therapy represents a less explored modality in wound care. The advantages of topical oxygen therapy include low cost, lack of systemic oxygen toxicity, and the ability to receive treatment at home, making the benefits of oxygen therapy available to a much larger population of patients. MATERIALS AND METHODS: Over 9 months, seven surgeons treated 58 wounds in 32 patients with topical oxygen with follow-up ranging from 1 to 8 months. The data presented herein is a retrospective analysis of the results we have achieved using topical oxygen on complex wounds. RESULTS: Thirty-eight wounds in 15 patients healed while on topical oxygen. An additional five wounds in five patients had preoperative oxygen therapy; all wounds initially healed postoperatively. In two patients, wounds recurred post-healing. In ten wounds, topical oxygen had no effect; and two of those patients went on to require limb amputation. There were no complications attributable to topical oxygen. Three patients died during therapy and one died in the first postoperative month from underlying medical problems. Two patients were lost to follow-up. CONCLUSIONS: In this case series, topical oxygen had no detrimental effects on wounds and showed beneficial indications in promoting wound healing. |
| | |
Authors:
|
Loree K. Kalliainen; Gayle M. Gordillo; Richard Schlanger; Chandan K. Sen |
Related Documents
:
|
22959789 - Reduction of traumatic, primary anterior shoulder dislocations with local anesthesia. 23109639 - Patient and implant survival following 4323 total hip replacements for acute femoral ne... 16040019 - The cell based dressing with living allogenic keratinocytes in the treatment of foot ul... 15243559 - Predictors of wound complications after laryngectomy: a study of over 2000 patients. 18937009 - Surgical treatment of the pilonidal disease: primary closure or flap reconstruction aft... 12733849 - Prospective study of morbidity associated with snakebite envenomation. 9322469 - Ultrasonographic guidance improves sensory block and onset time of three-in-one blocks. 19756889 - A surgical rat model of sleeve gastrectomy with staple technique: long-term weight loss... 21061789 - Late toxicities in concurrent chemoradiotherapy using high-dose-rate intracavitary brac... |
Publication Detail:
|
Type: JOURNAL ARTICLE |
Journal Detail:
|
Title: Pathophysiology : the official journal of the International Society for Pathophysiology / ISP Volume: 9 ISSN: - ISO Abbreviation: Pathophysiology Publication Date: 2003 Jan |
Date Detail:
|
Created Date: 2003-Oct-21 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9433813 Medline TA: Pathophysiology Country: - |
Other Details:
|
Languages: ENG Pagination: 81-87 Citation Subset: - |
Affiliation:
|
Department of Surgery, 512 Davis Heart & Lung Research Institute, The Ohio State University Medical Center, 473 West 12th Avenue, 43210, Columbus, OH, USA |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Retrospective investigation on management of salivary hypofunction concerning with serum zinc conten...
Next Document: Anti-inflammatory effect of Pelteobagrus nudiceps extract on rat model of CFA-induced pulmonary tube...