Document Detail

Topical mitomycin treatment for primary acquired melanosis of the conjunctiva.
MedLine Citation:
PMID:  12644763     Owner:  NLM     Status:  MEDLINE    
A case of primary acquired melanosis of the conjunctiva primarily treated with topical mitomycin chemotherapy is presented. The patient underwent treatment with one 2-week course of topical mitomycin 0.02% four times daily, followed 4 weeks later by a 2-week course of topical mitomycin 0.04% four times daily, followed by a 3-month course of topical mitomycin 0.02% twice daily. Map biopsies were performed after the initial two courses of mitomycin therapy and 12 months after all courses of mitomycin treatment had been completed. Complete resolution of the conjunctival pigmentation was noted after the final course of treatment. Map biopsies performed at 12 months following completion of treatment showed normal conjunctiva histopathologically. No recurrence of pigmentation was noted in follow-up 26 months after completion of treatment. Topical mitomycin chemotherapy may be a successful primary treatment for primary acquired melanosis of the conjunctiva.
Vernon Ho Yuen; David R Jordan; Seymour Brownstein; Michael W Dorey
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Ophthalmic plastic and reconstructive surgery     Volume:  19     ISSN:  0740-9303     ISO Abbreviation:  Ophthal Plast Reconstr Surg     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-03-19     Completed Date:  2003-04-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8508431     Medline TA:  Ophthal Plast Reconstr Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  149-51     Citation Subset:  IM    
The University of Ottawa Eye Institute, Ottawa, Ontario, Canada.
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MeSH Terms
Administration, Topical
Antibiotics, Antineoplastic / therapeutic use*
Conjunctival Diseases / drug therapy*,  pathology
Melanosis / drug therapy*,  pathology
Middle Aged
Mitomycin / therapeutic use*
Ophthalmic Solutions
Treatment Outcome
Reg. No./Substance:
0/Antibiotics, Antineoplastic; 0/Ophthalmic Solutions; 50-07-7/Mitomycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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