| Topical mitomycin C for the treatment of conjunctival and corneal epithelial dysplasia and neoplasia. | |
| | |
MedLine Citation:
|
PMID: 9439356 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: To evaluate the efficacy of topical mitomycin C in treating conjunctival and corneal epithelial dysplasia and neoplasia. METHODS: Seven eyes of seven patients with conjunctival and corneal epithelial dysplasia and neoplasia were treated with one drop of topical mitomycin C 0.04% four times a day for 7 days in alternate weeks. The patients' charts were reviewed retrospectively. Patients with either multiple recurrences or extensive ocular surface involvement were treated. In all eyes, the diagnosis of epithelial dysplasia or neoplasia was confirmed by histopathology before the onset of therapy. Patients were examined at least every 14 days during treatment and examined at intervals after completion of treatment. RESULTS: With topical mitomycin C, six eyes of seven patients had complete clinical regression of their conjunctival and corneal epithelial dysplasia and neoplasia. One eye of one patient had partial clinical regression of conjunctival and corneal epithelial dysplasia. Follow-up after completion of topical mitomycin C therapy and excision of residual disease ranged from 2 to 16 months (mean, 9 months; SD, 4.3 months) and was without clinical sign of recurrence. Topical mitomycin C therapy was associated with transitory ocular discomfort, conjunctival injection, tearing, photophobia, and punctate epithelial keratopathy. CONCLUSION: In this small series of eyes, topical mitomycin C was effective as a treatment for conjunctival and corneal epithelial dysplasia and neoplasia. |
| | |
Authors:
|
M W Wilson; J L Hungerford; S M George; S A Madreperla |
Related Documents
:
|
12578076 - Effects of digital filtering on the parameters of impulse-like eye movements. 1741126 - Effect of topical mitomycin c on glaucoma filtration surgery in monkeys. 7591636 - Retroperfusion studies of the aqueous outflow system. part 2: studies in human eyes. 2433656 - 5-fluorouracil and glaucoma filtering surgery. iii. intermediate follow-up of a pilot s... 11774866 - Space environment, electromagnetic fields, and circadian rhythm. 23381656 - Altered tgf-β2 and bfgf expression in scleral desmocytes from an experimentally-induce... |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: American journal of ophthalmology Volume: 124 ISSN: 0002-9394 ISO Abbreviation: Am. J. Ophthalmol. Publication Date: 1997 Sep |
Date Detail:
|
Created Date: 1998-01-28 Completed Date: 1998-01-28 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0370500 Medline TA: Am J Ophthalmol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 303-11 Citation Subset: AIM; IM |
Affiliation:
|
Ocular Oncology Unit, St Bartholomew's Hospital, London, UK. wilsonm@jove.UCHSC.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aged, 80 and over Antibiotics, Antineoplastic / adverse effects, therapeutic use* Carcinoma in Situ / drug therapy*, pathology Conjunctival Neoplasms / drug therapy*, pathology Corneal Diseases / drug therapy*, pathology Epithelium, Corneal / drug effects*, pathology Eye Neoplasms / drug therapy*, pathology Female Follow-Up Studies Humans Male Middle Aged Mitomycin / adverse effects, therapeutic use* Ophthalmic Solutions Remission Induction Retrospective Studies Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Antibiotics, Antineoplastic; 0/Ophthalmic Solutions; 50-07-7/Mitomycin |
| Comments/Corrections | |
Comment In:
|
Am J Ophthalmol. 1997 Sep;124(3):381-3
[PMID:
9439364
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Hemodynamic and visual function effects of oral nifedipine in patients with normal-tension glaucoma.
Next Document: Corneal topographic evaluation of decentration in photorefractive keratectomy: treatment displacemen...