Document Detail

Topical mitomycin C for the treatment of conjunctival and corneal epithelial dysplasia and neoplasia.
MedLine Citation:
PMID:  9439356     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To evaluate the efficacy of topical mitomycin C in treating conjunctival and corneal epithelial dysplasia and neoplasia. METHODS: Seven eyes of seven patients with conjunctival and corneal epithelial dysplasia and neoplasia were treated with one drop of topical mitomycin C 0.04% four times a day for 7 days in alternate weeks. The patients' charts were reviewed retrospectively. Patients with either multiple recurrences or extensive ocular surface involvement were treated. In all eyes, the diagnosis of epithelial dysplasia or neoplasia was confirmed by histopathology before the onset of therapy. Patients were examined at least every 14 days during treatment and examined at intervals after completion of treatment. RESULTS: With topical mitomycin C, six eyes of seven patients had complete clinical regression of their conjunctival and corneal epithelial dysplasia and neoplasia. One eye of one patient had partial clinical regression of conjunctival and corneal epithelial dysplasia. Follow-up after completion of topical mitomycin C therapy and excision of residual disease ranged from 2 to 16 months (mean, 9 months; SD, 4.3 months) and was without clinical sign of recurrence. Topical mitomycin C therapy was associated with transitory ocular discomfort, conjunctival injection, tearing, photophobia, and punctate epithelial keratopathy. CONCLUSION: In this small series of eyes, topical mitomycin C was effective as a treatment for conjunctival and corneal epithelial dysplasia and neoplasia.
M W Wilson; J L Hungerford; S M George; S A Madreperla
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  American journal of ophthalmology     Volume:  124     ISSN:  0002-9394     ISO Abbreviation:  Am. J. Ophthalmol.     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1998-01-28     Completed Date:  1998-01-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370500     Medline TA:  Am J Ophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  303-11     Citation Subset:  AIM; IM    
Ocular Oncology Unit, St Bartholomew's Hospital, London, UK.
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MeSH Terms
Aged, 80 and over
Antibiotics, Antineoplastic / adverse effects,  therapeutic use*
Carcinoma in Situ / drug therapy*,  pathology
Conjunctival Neoplasms / drug therapy*,  pathology
Corneal Diseases / drug therapy*,  pathology
Epithelium, Corneal / drug effects*,  pathology
Eye Neoplasms / drug therapy*,  pathology
Follow-Up Studies
Middle Aged
Mitomycin / adverse effects,  therapeutic use*
Ophthalmic Solutions
Remission Induction
Retrospective Studies
Treatment Outcome
Reg. No./Substance:
0/Antibiotics, Antineoplastic; 0/Ophthalmic Solutions; 50-07-7/Mitomycin
Comment In:
Am J Ophthalmol. 1997 Sep;124(3):381-3   [PMID:  9439364 ]

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