Document Detail

Topical mitomycin-C for subepithelial fibrosis after refractive corneal surgery.
MedLine Citation:
PMID:  10647725     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the effectiveness of mitomycin-C (MMC), 0.02%, in preventing recurrence of corneal subepithelial fibrosis after debridement and/or keratectomy in patients who have undergone refractive corneal surgery. DESIGN: Noncomparative case series. PARTICIPANTS: Eight eyes of five patients with corneal subepithelial fibrosis who had previously undergone radial keratotomy (n = 4) or photorefractive keratectomy (n = 4). INTERVENTION: All eyes underwent epithelial debridement followed by a single intraoperative application of MMC (0.02%) for 2 minutes followed by saline irrigation. The eyes were then patched, or a bandage contact lens placed until epithelial healing was complete. MAIN OUTCOME MEASURES: Corneal clarity and best-corrected visual acuity (BCVA). RESULTS: In all cases, the cornea remained clear with no recurrence throughout the follow-up period (6-25 mos., mean, 13.8 mos). No adverse reactions were reported. BCVA improved in all cases. CONCLUSIONS: Subepithelial fibrosis can be a visually disabling condition after refractive corneal surgery. Topical application of MMC (0.02%) may be a successful method of preventing recurrence of subepithelial fibrosis after debridement.
P A Majmudar; S L Forstot; R F Dennis; V S Nirankari; R E Damiano; R Brenart; R J Epstein
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Ophthalmology     Volume:  107     ISSN:  0161-6420     ISO Abbreviation:  Ophthalmology     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-01-28     Completed Date:  2000-01-28     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7802443     Medline TA:  Ophthalmology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  89-94     Citation Subset:  IM    
Cornea Service, Department of Ophthalmology, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612, USA.
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MeSH Terms
Administration, Topical
Epithelium, Corneal / drug effects*,  pathology,  surgery
Fibrosis / drug therapy,  etiology
Keratotomy, Radial / adverse effects*
Lasers, Excimer
Middle Aged
Mitomycin / administration & dosage,  therapeutic use*
Nucleic Acid Synthesis Inhibitors / administration & dosage,  therapeutic use*
Photorefractive Keratectomy / adverse effects*
Refractive Surgical Procedures*
Treatment Outcome
Visual Acuity
Wound Healing
Reg. No./Substance:
0/Nucleic Acid Synthesis Inhibitors; 50-07-7/Mitomycin
Comment In:
Ophthalmology. 2001 Feb;108(2):239-40   [PMID:  11158781 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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