Document Detail

Topical minoxidil for hair regrowth.
MedLine Citation:
PMID:  6384289     Owner:  NLM     Status:  MEDLINE    
Minoxidil, a potent peripheral vasodilator used orally for refractory hypertension, has produced hypertrichosis. To determine the efficacy and safety of 1% or 5% topical minoxidil for the stimulation of scalp hair regrowth, we studied fifteen normotensive patients, five with androgenic alopecia and ten with alopecia areata diagnosed clinically and by biopsy, for 12 months. Three of five patients with androgenic alopecia using 5% minoxidil for 12 months noted hair regrowth, ranging from minimally observable hair to an appreciable restoration of larger, pigmented, terminal hair in one patient. Among the patients with androgenic alopecia, regrowth response corresponded to the serum minoxidil blood levels. None of the patients with alopecia areata receiving either 1% or 5% minoxidil noted hair regrowth despite comparable minoxidil blood levels. Improved local absorption of topical minoxidil solution may promote hair regrowth in androgenic alopecia.
E E Vanderveen; C N Ellis; S Kang; P Case; J T Headington; J J Voorhees; N A Swanson
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of the American Academy of Dermatology     Volume:  11     ISSN:  0190-9622     ISO Abbreviation:  J. Am. Acad. Dermatol.     Publication Date:  1984 Sep 
Date Detail:
Created Date:  1984-11-01     Completed Date:  1984-11-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7907132     Medline TA:  J Am Acad Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  416-21     Citation Subset:  IM    
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MeSH Terms
Administration, Topical
Alopecia / drug therapy*,  etiology
Alopecia Areata / drug therapy
Androgens / metabolism
Clinical Trials as Topic
Double-Blind Method
Ethanol / administration & dosage
Follow-Up Studies
Hair / drug effects*,  growth & development
Middle Aged
Minoxidil / administration & dosage*
Propylene Glycols / administration & dosage
Pyrimidines / administration & dosage*
Time Factors
Reg. No./Substance:
0/Androgens; 0/Propylene Glycols; 0/Pyrimidines; 0/Solutions; 0/Vehicles; 38304-91-5/Minoxidil; 64-17-5/Ethanol; 7732-18-5/Water

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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